Synthesizing and staining manganese oxide nanoparticles for cytotoxicity and cellular uptake investigation

• Published in: Biochimica et biophysica acta Vol. 1840; no. 1; pp. 428 - 433
• Main Authors: Omid, Hamed, Oghabian, Mohammad Ali, Ahmadi, Reza, Shahbazi, Narges, Hosseini, Hamid Reza Madaah, Shanehsazzadeh, Saeed, Zangeneh, Rashin Namivandi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2014
• Subjects: 2,5-dihydroxybenzoic acid; adverse effects; Apoptosis; Cell Proliferation; Cell uptake; chelates; color; Cytotoxicity; Enzyme-Linked Immunosorbent Assay; Fourier transform infrared spectroscopy; gadolinium; Gentisates - chemistry; HeLa Cells; Humans; hydrophilicity; light scattering; Magnetic Resonance Imaging; Manganese Compounds - chemistry; Manganese oxide nanoparticle; manganese oxides; MRI contrast agent; nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Oxides - chemistry; Particle Size; protons; Prussian blue staining; Spectrophotometry, Atomic; Spectroscopy, Fourier Transform Infrared; staining; surfactants; tissues; transmission electron microscopes; X-Ray Diffraction; Manganese oxide nanoparticle; Cell uptake; Cytotoxicity; MRI contrast agent; Prussian blue staining

For decades, contrast agents have been used to reduce longitudinal (T1) or transverse (T2) relaxation times. High toxicity of gadolinium-based contrast agents leads researchers to new T1 contrast agents. Manganese oxide (MnO) nanoparticle (NP) with the lower peril and good enough signal change abili...