Much more than you expected: The non-DHFR-mediated effects of methotrexate - Sramek, Martin; Neradil, Jakub; Veselska, Renata (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Animals; autoimmune diseases; Cell differentiation; dihydrofolate reductase; DNA methylation; Epigenetic regulation; folic acid; Folic Acid - metabolism; Folic Acid Antagonists - pharmacology; Folic Acid Antagonists - therapeutic use; Histone acetylation; Humans; Methotrexate; Methotrexate - pharmacology; Methotrexate - therapeutic use; Oxidative stress; pharmacology; Signal Transduction - drug effects; Tetrahydrofolate Dehydrogenase - metabolism; therapeutics; ALL; MAT; Oxidative stress; DHF; HDACs; MTXPGs; Glo1; Epigenetic regulation; RFC; MTX; FGAR; ATIC; THF; TMECG; FPGS; E2F1; DNA methylation; Methotrexate; HDACi; SAHA; MTHFR; MITF; PP2A; Histone acetylation; Cell differentiation; FAICAR; DHFR; HDACis; ROS; GAR; HATs; AICAR; SAH; ATRA; GART; ADA; SAM; TS