New quantitative automated model to simulate bacterial dissemination in human tissue during irrigation of contaminated wounds

• Published in: European cells & materials Vol. 42; pp. 63 - 71
• Main Authors: Brochhausen, C, Froschermeier, F, Alt, V, Pfeifer, C, Mayr, A, Weiss, I, Babel, M, Siegmund, H, Kerschbaum, M
• Format: Journal Article
• Language: English
• Published: Switzerland Forum Multimedia Publishing LLC 03.08.2021
• Subjects: automated particle count; Bacteria; digital whole slide image processing; Humans; jet lavage; microparticles; soft tissue contamination; Staphylococcal Infections; Staphylococcus aureus; Therapeutic Irrigation; Wound Healing

This study presents a simple and cost-effective model using microparticles to simulate the bacterial distribution pattern in soft tissue after low- and high-pressure irrigation. Silica coated iron microparticles [comparable diameter (1 µm) and weight (0.8333 pg) to Staphylococcus aureus] were applie...