BARD1 is an ATPase activating protein for OLA1

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 5; p. 130099
• Main Authors: Chen, Ting, Yeh, Hung-Wei, Chen, Po-Pang, Huang, Wei-Ting, Wu, Chu-Ya, Liao, Tzu-Chen, Lin, Shiou-Lan, Chen, Yi-Yun, Lin, Kai-Ti, Hsu, Shang-Te Danny, Cheng, Hui-Chun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2022
• Subjects: Adenosine Triphosphatases - metabolism; adenosinetriphosphatase; ATPase activation; BARD1; BRCT; BUDR motif; Cell Cycle; Centrosome - metabolism; centrosomes; enzyme kinetics; guanosinetriphosphatase; mutants; mutation; neoplasms; OLA1; P-loop NTPase; tumor suppressor proteins; Tumor Suppressor Proteins - chemistry; Ubiquitin-Protein Ligases - metabolism; BARD1; OLA1; ATPase activation; BUDR motif; BRCT; P-loop NTPase

OLA1 is a P-loop ATPase, implicated in centrosome duplication through the interactions with tumor suppressors BRCA1 and BARD1. Disruption of the interaction of OLA1 with BARD1 results in centrosome amplification. However, the molecular interplay and mechanism of the OLA1-BARD1 complex remain elusive...