Mistranslation: from adaptations to applications

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 11; pp. 3070 - 3080
• Main Authors: Hoffman, Kyle S., O'Donoghue, Patrick, Brandl, Christopher J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: accidents; Adaptation, Biological - genetics; Adaptive response; alleles; amino acids; Animals; biomedical research; Codon - genetics; Evolution; Evolution, Molecular; Genetic Code; Humans; metagenomics; Mistranslation; Mutation - physiology; nucleotide sequences; Polymorphism, Genetic - physiology; Protein Biosynthesis - genetics; Protein Engineering - methods; Protein Engineering - trends; proteins; proteome; proteomics; selection pressure; sequence analysis; synthetic biology; Transfer RNA; Translation; translation (genetics); Mistranslation; Genetic code; Evolution; Translation; Adaptive response; Transfer RNA

The conservation of the genetic code indicates that there was a single origin, but like all genetic material, the cell's interpretation of the code is subject to evolutionary pressure. Single nucleotide variations in tRNA sequences can modulate codon assignments by altering codon-anticodon pair...