Evaluation of chitosan nanoformulations as potent anti-HIV therapeutic systems

• Published in: Biochimica et biophysica acta Vol. 1840; no. 1; pp. 476 - 484
• Main Authors: Ramana, Lakshmi Narashimhan, Sharma, Shilpee, Sethuraman, Swaminathan, Ranga, Udaykumar, Krishnan, Uma Maheswari
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2014
• Subjects: Antiretroviral; antiretroviral agents; Calorimetry, Differential Scanning; Chitosan; Chitosan - administration & dosage; Chitosan - chemistry; confocal microscopy; cytotoxicity; differential scanning calorimetry; Drug Carriers; drugs; encapsulation; flow cytometry; HEK293 Cells; HIV Infections - drug therapy; HIV Protease Inhibitors - pharmacology; HIV-1 - physiology; Human immunodeficiency virus 1; Humans; Jurkat Cells; metabolism; Microscopy, Electron, Transmission; Nanocarrier; nanocarriers; nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Particle Size; Phagocytosis; proteinase inhibitors; Saquinavir; Saquinavir - pharmacology; T-lymphocytes; transmission electron microscopy; zeta potential; Antiretroviral; Saquinavir; Nanocarrier; Chitosan

Antiretroviral Therapy (ART) is currently the major therapeutic intervention in the treatment of AIDS. ART, however, is severely limited due to poor availability, high cytotoxicity, and enhanced metabolism and clearance of the drug molecules by the renal system. The use of nanocarriers encapsulating...