Simulation of the effects of negative thermal gradients on separation performance of gas chromatography

• Published in: Journal of Chromatography A Vol. 1640; p. 461943
• Main Authors: Leppert, Jan, Blumberg, Leonid M., Wüst, Matthias, Boeker, Peter
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2021
• Subjects: Chromatography, Gas - methods; Computer Simulation; Gas chromatography; gases; separation; Simulation; simulation models; solutes; Temperature; temperature profiles; Thermal gradient; Velocity gradient; Gas chromatography; Simulation; Velocity gradient; Thermal gradient

•Model to simulate ideal basic separation (IBS) including deviations from IBS.•Adding negative gradients to IBS reduces the separation.•Negative gradients partly compensate for broad sample injection and for gas decompression. The effect of a gradient of solute velocity on the chromatographic separa...