A new pseudopolymorph of berberine chloride: crystal structure and Hirshfeld surface analysis

A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2 -7λ -[1,3]dioxolo[4,5- ]iso-quinolino-[3,2- ]isoquinolin-7-ylium chloride methanol monosolvate, C H NO ·Cl ·CH OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations fo...

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Published inActa crystallographica. Section E, Crystallographic communications Vol. 78; no. Pt 5; pp. 468 - 472
Main Authors Kornilova, Tatiana, Glebov, Viktor, Castañeda, Raúl, Timofeeva, Tatiana V
Format Journal Article
LanguageEnglish
Published England International Union of Crystallography 01.05.2022
Subjects
crystal structure
hirshfeld surface analysis
methanol solvate
Research Communications
stacking interactions
crystal structure
stacking inter­actions
Hirshfeld surface analysis
methanol solvate
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Abstract A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2 -7λ -[1,3]dioxolo[4,5- ]iso-quinolino-[3,2- ]isoquinolin-7-ylium chloride methanol monosolvate, C H NO ·Cl ·CH OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetra-hydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the inter-molecular inter-actions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.
AbstractList A new pseudopolymorph of berberine, 9,10-dimethoxy-5,6-dihydro-2 H -7λ 5 -[1,3]dioxolo[4,5- g ]isoquinolino[3,2- a ]isoquinolin-7-ylium chloride methanol monosolvate, C 20 H 18 NO 4 + ·Cl − ·CH 3 OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetrahydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the intermolecular interactions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.
A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2 -7λ -[1,3]dioxolo[4,5- ]iso-quinolino-[3,2- ]isoquinolin-7-ylium chloride methanol monosolvate, C H NO ·Cl ·CH OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetra-hydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the inter-molecular inter-actions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.
A new pseudopolymorph of berberine, 9,10-dimethoxy-5,6-dihydro-2H-7λ5-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ylium chloride methanol monosolvate, C20H18NO4+·Cl−·CH3OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetrahydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the intermolecular interactions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.
The crystal structure of methanol solvate of berberine chloride, 9,10-dimeth­oxy-5,6-di­hydro-2 H -7λ 5 -[1,3]dioxolo[4,5- g ]iso­quinolino­[3,2- a ]isoquinolin-7-ylium chloride methanol monosolvate, was determined and its Hirshfeld surface analysis was performed. A new pseudopolymorph of berberine, 9,10-dimeth­oxy-5,6-di­hydro-2 H -7λ 5 -[1,3]dioxolo[4,5- g ]iso­quinolino­[3,2- a ]isoquinolin-7-ylium chloride methanol monosolvate, C 20 H 18 NO 4 + ·Cl − ·CH 3 OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetra­hydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the inter­molecular inter­actions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.
A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2H-7λ5-[1,3]dioxolo[4,5-g]iso-quinolino-[3,2-a]isoquinolin-7-ylium chloride methanol monosolvate, C20H18NO4 +·Cl-·CH3OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetra-hydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the inter-molecular inter-actions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2H-7λ5-[1,3]dioxolo[4,5-g]iso-quinolino-[3,2-a]isoquinolin-7-ylium chloride methanol monosolvate, C20H18NO4 +·Cl-·CH3OH, was obtained during co-crystallization of berberine chloride with malonic acid from methanol. The berberine cations form dimers, which are further packed in stacks. The title structure was compared with other reported solvates of berberine chloride: its dihydrate, tetra-hydrate, and ethanol solvate hemihydrate. Hirshfeld analysis was performed to show the inter-molecular inter-actions in the crystal structure of the title compound, and its fingerprint plots were compared with those of the already studied solvates.
Author Timofeeva, Tatiana V
Glebov, Viktor
Kornilova, Tatiana
Castañeda, Raúl
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stacking inter­actions
Hirshfeld surface analysis
methanol solvate
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Snippet A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2 -7λ -[1,3]dioxolo[4,5- ]iso-quinolino-[3,2- ]isoquinolin-7-ylium chloride methanol...
A new pseudopolymorph of berberine, 9,10-dimethoxy-5,6-dihydro-2 H -7λ 5 -[1,3]dioxolo[4,5- g ]isoquinolino[3,2- a ]isoquinolin-7-ylium chloride methanol...
A new pseudopolymorph of berberine, 9,10-dimeth-oxy-5,6-di-hydro-2H-7λ5-[1,3]dioxolo[4,5-g]iso-quinolino-[3,2-a]isoquinolin-7-ylium chloride methanol...
The crystal structure of methanol solvate of berberine chloride, 9,10-dimeth­oxy-5,6-di­hydro-2 H -7λ 5 -[1,3]dioxolo[4,5- g ]iso­quinolino­[3,2- a...
A new pseudopolymorph of berberine, 9,10-dimethoxy-5,6-dihydro-2H-7λ5-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ylium chloride methanol monosolvate,...
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hirshfeld surface analysis
methanol solvate
Research Communications
stacking interactions
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Title A new pseudopolymorph of berberine chloride: crystal structure and Hirshfeld surface analysis
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