Activation of the human mirror neuron system during the observation of the manipulation of virtual tools in the absence of a visible effector limb
•Subjects manipulated virtual tools in a digital game and watched the replays.•Virtual limbs were not necessary to produce extended mirror activity.•M1 showed a reduced BOLD during action observation.•Value to the field of action observation neurorehabilitation. This work explores the mirror neuron...
Saved in:
| Published in | Neuroscience letters Vol. 555; pp. 220 - 224 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
25.10.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | •Subjects manipulated virtual tools in a digital game and watched the replays.•Virtual limbs were not necessary to produce extended mirror activity.•M1 showed a reduced BOLD during action observation.•Value to the field of action observation neurorehabilitation.
This work explores the mirror neuron system activity produced by the observation of virtual tool manipulations in the absence of a visible effector limb. Functional MRI data was obtained from healthy right-handed participants who manipulated a virtual paddle in the context of a digital game and watched replays of their actions. The results show how action observation produced extended bilateral activations in the parietofrontal mirror neuron system. At the same time, three regions in the left hemisphere (in the primary motor and the primary somatosensory cortex, the supplementary motor area and the dorsolateral prefrontal cortex) showed a reduced BOLD, possibly related with the prevention of inappropriate motor execution. These results can be of interest for researchers and developers working in the field of action observation neurorehabilitation. |
|---|---|
| AbstractList | This work explores the mirror neuron system activity produced by the observation of virtual tool manipulations in the absence of a visible effector limb. Functional MRI data was obtained from healthy right-handed participants who manipulated a virtual paddle in the context of a digital game and watched replays of their actions. The results show how action observation produced extended bilateral activations in the parietofrontal mirror neuron system. At the same time, three regions in the left hemisphere (in the primary motor and the primary somatosensory cortex, the supplementary motor area and the dorsolateral prefrontal cortex) showed a reduced BOLD, possibly related with the prevention of inappropriate motor execution. These results can be of interest for researchers and developers working in the field of action observation neurorehabilitation. This work explores the mirror neuron system activity produced by the observation of virtual tool manipulations in the absence of a visible effector limb. Functional MRI data was obtained from healthy right-handed participants who manipulated a virtual paddle in the context of a digital game and watched replays of their actions. The results show how action observation produced extended bilateral activations in the parietofrontal mirror neuron system. At the same time, three regions in the left hemisphere (in the primary motor and the primary somatosensory cortex, the supplementary motor area and the dorsolateral prefrontal cortex) showed a reduced BOLD, possibly related with the prevention of inappropriate motor execution. These results can be of interest for researchers and developers working in the field of action observation neurorehabilitation.This work explores the mirror neuron system activity produced by the observation of virtual tool manipulations in the absence of a visible effector limb. Functional MRI data was obtained from healthy right-handed participants who manipulated a virtual paddle in the context of a digital game and watched replays of their actions. The results show how action observation produced extended bilateral activations in the parietofrontal mirror neuron system. At the same time, three regions in the left hemisphere (in the primary motor and the primary somatosensory cortex, the supplementary motor area and the dorsolateral prefrontal cortex) showed a reduced BOLD, possibly related with the prevention of inappropriate motor execution. These results can be of interest for researchers and developers working in the field of action observation neurorehabilitation. •Subjects manipulated virtual tools in a digital game and watched the replays.•Virtual limbs were not necessary to produce extended mirror activity.•M1 showed a reduced BOLD during action observation.•Value to the field of action observation neurorehabilitation. This work explores the mirror neuron system activity produced by the observation of virtual tool manipulations in the absence of a visible effector limb. Functional MRI data was obtained from healthy right-handed participants who manipulated a virtual paddle in the context of a digital game and watched replays of their actions. The results show how action observation produced extended bilateral activations in the parietofrontal mirror neuron system. At the same time, three regions in the left hemisphere (in the primary motor and the primary somatosensory cortex, the supplementary motor area and the dorsolateral prefrontal cortex) showed a reduced BOLD, possibly related with the prevention of inappropriate motor execution. These results can be of interest for researchers and developers working in the field of action observation neurorehabilitation. |
| Author | Navarrete, Gorka Rodríguez-Hernández, Antonio F. González-Mora, José L. Modroño, Cristián |
| Author_xml | – sequence: 1 givenname: Cristián surname: Modroño fullname: Modroño, Cristián email: cmodrono@ull.edu.es organization: Department of Physiology, University of La Laguna, Campus de CC. de la Salud, 38071 Tenerife, Spain – sequence: 2 givenname: Gorka surname: Navarrete fullname: Navarrete, Gorka organization: Laboratory of Cognitive and Social Neuroscience (LaNCyS), UDP-INECO Foundation Core on Neuroscience (UIFCoN), Universidad Diego Portales, Santiago, Chile – sequence: 3 givenname: Antonio F. surname: Rodríguez-Hernández fullname: Rodríguez-Hernández, Antonio F. organization: Department of Physiology, University of La Laguna, Campus de CC. de la Salud, 38071 Tenerife, Spain – sequence: 4 givenname: José L. surname: González-Mora fullname: González-Mora, José L. organization: Department of Physiology, University of La Laguna, Campus de CC. de la Salud, 38071 Tenerife, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24080372$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkctq3DAUhkVJaSZp36AUL7uxq6ttdVEIoTcIdNOuhWwdNRpkaSrJA3mNPHE1M2mgXTQrgfR956D_v0BnIQZA6DXBHcGkf7ftAqweSkcxYR2WHeb8GdqQcaDtIAd6hjaYYd4yyfE5ush5izEWRPAX6JxyPGI20A26v5qL2-viYmiibcotNLfrokOzuJRiauqOVJ_yXS6wNGZNLvw8UnHKkP4Wq-Z2q3-827tUVu2bEqPPjQtHSFcvzHB415XIbvLQgLUwl7rOu2V6iZ5b7TO8ejgv0Y9PH79ff2lvvn3-en11085MitL2vakf0jPTDEbNDQUzABaTGSfLaT8OREgYWS-FJWbSYKTprWVGDwBMCMwu0dvT3F2Kv1bIRS0uz-C9DhDXrIgg_SCIpOxplAtJBKaEV_TNA7pOCxi1S27R6U79ibwC_ATMKeacwD4iBKtDs2qrTs2qQ7MKS1Wbrdr7f7TZlWPUJWnnn5I_nGSoee4dJJVnd6jBuFSDVya6_w_4Df0MxEY |
| CitedBy_id | crossref_primary_10_3390_info15080501 crossref_primary_10_1177_2055668319859140 crossref_primary_10_1186_s12984_017_0268_4 crossref_primary_10_4236_aa_2014_42013 crossref_primary_10_1002_brb3_3049 crossref_primary_10_1111_nyas_14554 crossref_primary_10_1007_s13311_020_00882_x crossref_primary_10_1089_cyber_2020_0231 crossref_primary_10_1007_s11682_017_9804_x crossref_primary_10_1152_jn_00383_2022 crossref_primary_10_1371_journal_pone_0291528 crossref_primary_10_1016_j_jamda_2021_01_076 crossref_primary_10_1371_journal_pone_0121562 crossref_primary_10_1080_03057240_2023_2300503 crossref_primary_10_1002_hbm_24969 crossref_primary_10_3390_electronics8121466 |
| Cites_doi | 10.1093/oso/9780198510697.003.0017 10.1111/j.1460-9568.2001.01385.x 10.1016/j.neuroimage.2007.02.003 10.1016/0028-3932(71)90067-4 10.1126/science.1093535 10.1093/cercor/bhi007 10.1093/cercor/bhn181 10.1093/brain/119.2.593 10.1162/089892904322755601 10.1068/p7027 10.1016/j.tics.2003.12.008 10.1152/jn.1996.75.1.233 10.1016/j.concog.2008.03.004 10.1371/journal.pbio.0030079 10.1162/0898929053124910 10.1177/1545968309354536 10.1016/j.jneumeth.2011.05.014 10.1016/j.bandc.2012.11.001 10.1016/j.brainres.2009.11.065 10.1001/archneurol.2009.41 10.1097/00146965-200603000-00007 10.1016/j.neuroimage.2003.11.013 10.1016/j.neuroimage.2012.09.026 10.1016/S1053-8119(02)00041-1 10.1111/ejn.12157 10.1016/j.neuroimage.2010.01.103 10.1016/j.neuroimage.2010.01.052 10.1002/ana.410320206 10.1016/j.neuropsychologia.2012.05.009 10.1016/j.neuroscience.2010.05.080 10.1038/nn1675 10.1017/S1092852900024202 10.1186/1743-0003-7-48 10.1523/JNEUROSCI.23-10-03963.2003 10.1016/j.neuroimage.2004.12.005 10.1093/brain/123.6.1216 10.1016/j.neuroimage.2007.06.008 |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier Ireland Ltd Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
| Copyright_xml | – notice: 2013 Elsevier Ireland Ltd – notice: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7TK |
| DOI | 10.1016/j.neulet.2013.09.044 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic Neurosciences Abstracts |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic Neurosciences Abstracts |
| DatabaseTitleList | Neurosciences Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1872-7972 |
| EndPage | 224 |
| ExternalDocumentID | 24080372 10_1016_j_neulet_2013_09_044 S0304394013008689 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -~X .~1 0R~ 123 1B1 1RT 1~. 1~5 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AADPK AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXLA AAXUO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGUBO AGWIK AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPCBC SSN SSZ T5K WH7 YCJ ~G- .55 .GJ 29N AAQXK AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADIYS ADMUD ADNMO AEIPS AETEA AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION FEDTE FGOYB G-2 HMQ HVGLF HZ~ MVM R2- SEW SNS SSH WUQ X7M ZGI ZXP ZY4 CGR CUY CVF ECM EIF NPM 7X8 7TK EFKBS |
| ID | FETCH-LOGICAL-c395t-66d000ac3a3e8a4d2ed7e05bd8bf42687159e83695f1dbaed9d6ff3da7ee35503 |
| IEDL.DBID | .~1 |
| ISSN | 0304-3940 1872-7972 |
| IngestDate | Tue Aug 05 10:19:01 EDT 2025 Fri Jul 11 07:09:52 EDT 2025 Thu Apr 03 07:07:29 EDT 2025 Tue Jul 01 04:07:11 EDT 2025 Thu Apr 24 23:16:10 EDT 2025 Fri Feb 23 02:24:21 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | fMRI Neurorehabilitation Mirror neurons Tool use Virtual reality |
| Language | English |
| License | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c395t-66d000ac3a3e8a4d2ed7e05bd8bf42687159e83695f1dbaed9d6ff3da7ee35503 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 24080372 |
| PQID | 1459150214 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_1516751923 proquest_miscellaneous_1459150214 pubmed_primary_24080372 crossref_primary_10_1016_j_neulet_2013_09_044 crossref_citationtrail_10_1016_j_neulet_2013_09_044 elsevier_sciencedirect_doi_10_1016_j_neulet_2013_09_044 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-10-25 |
| PublicationDateYYYYMMDD | 2013-10-25 |
| PublicationDate_xml | – month: 10 year: 2013 text: 2013-10-25 day: 25 |
| PublicationDecade | 2010 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Neuroscience letters |
| PublicationTitleAlternate | Neurosci Lett |
| PublicationYear | 2013 |
| Publisher | Elsevier Ireland Ltd |
| Publisher_xml | – name: Elsevier Ireland Ltd |
| References | Newman-Norlund, van Schie, van Hoek, Cuijpers, Bekkering (bib0155) 2010; 1315 Vingerhoets, Honore, Vandekerckhove, Nys, Vandemaele, Achten (bib0200) 2010; 169 Modroño, Rodriguez-Hernandez, Marcano, Navarrete, Burunat, Ferrer, Monserrat, Gonzalez-Mora (bib0150) 2011; 202 Farrer, Franck, Georgieff, Frith, Decety, Jeannerod (bib0070) 2003; 18 Bischoff, Zentgraf, Lorey, Pilgramm, Balser, Baumgartner, Hohmann, Stark, Vaitl, Munzert (bib0005) 2012; 50 Filimon, Nelson, Hagler, Serenoa (bib0080) 2007; 37 Prochnow, Bermúdez i Badia, Schmidt, Duff, Brunheim, Kleiser, Seitz, Verschure (bib0175) 2013; 37 Jenkins, Jahanshahi, Jueptner, Passingham, Brooks (bib0135) 2000; 123 Nichols, Brett, Andersson, Wager, Poline (bib0160) 2005; 25 Bucchioni, Cavallo, Ippolito, Marton, Castiello (bib0010) 2013; 81 Gazzola, Keysers (bib0105) 2009; 19 Gozli, Brown (bib0115) 2011; 40 David, Newen, Vogeley (bib0055) 2008; 17 Cameirao, Bermudez i Badia, Duarte Oller, Verschure (bib0040) 2010; 7 Cattaneo, Rizzolatti (bib0050) 2009; 66 Gazzola, Rizzolatti, Wicker, Keysers (bib0110) 2007; 35 Buccino, Lui, Canessa, Patteri, Lagravinese, Benuzzi, Porro, Rizzolatti (bib0020) 2004; 16 Frith (bib0085) 2000 Sale, Franceschini (bib0185) 2012; 48 Garrison, Winstein, Aziz-Zadeh (bib0100) 2010; 24 Logothetis (bib0140) 2003; 23 Singer, Seymour, O’Doherty, Kaube, Dolan, Frith (bib0195) 2004; 303 Maravita, Iriki (bib0145) 2004; 8 Buccino, Solodkin, Small (bib0025) 2006; 19 Cameirao, Bermudez i Badia, Zimmerli, Duarte Oller, Verschure (bib0045) 2007 Iacoboni, Molnar-Szakacs, Gallese, Buccino, Mazziotta, Rizzolatti (bib0130) 2005; 3 Buccino, Binkofski, Fink, Fadiga, Fogassi, Gallese, Seitz, Zilles, Rizzolatti, Freund (bib0015) 2001; 13 Iacoboni, Lieberman, Knowlton, Molnar-Szakacs, Moritz, Throop, Fiske (bib0125) 2004; 21 Shmuel, Augath, Oeltermann, Logothetis (bib0190) 2006; 9 Cabinio, Blasi, Borroni, Montagna, Iadanza, Falini, Cerri (bib0030) 2010; 51 Playford, Jenkins, Passingham, Nutt, Frackowiak, Brooks (bib0170) 1992; 32 Deiber, Ibanez, Sadato, Hallett (bib0060) 1996; 75 Di Dio, Di Cesare, Higuchi, Roberts, Vogt, Rizzolatti (bib0065) 2013; 64 Gallese, Fadiga, Fogassi, Rizzolatti (bib0095) 2002; 19 Calvo-Merino, Glaser, Grezes, Passingham, Haggard (bib0035) 2005; 15 Oldfield (bib0165) 1971; 9 Hoffman, Richards, Bills, Van Oostrom, Magula, Seibel, Sharar (bib0120) 2006; 11 Ferrari, Rozzi, Fogassi (bib0075) 2005; 17 Redcay, Dodell-Feder, Pearrow, Mavros, Kleiner, Gabrieli, Saxe (bib0180) 2010; 50 Gallese, Fadiga, Fogassi, Rizzolatti (bib0090) 1996; 119 Shmuel (10.1016/j.neulet.2013.09.044_bib0190) 2006; 9 Buccino (10.1016/j.neulet.2013.09.044_bib0025) 2006; 19 Cattaneo (10.1016/j.neulet.2013.09.044_bib0050) 2009; 66 Cameirao (10.1016/j.neulet.2013.09.044_bib0045) 2007 Gazzola (10.1016/j.neulet.2013.09.044_bib0110) 2007; 35 Redcay (10.1016/j.neulet.2013.09.044_bib0180) 2010; 50 Filimon (10.1016/j.neulet.2013.09.044_bib0080) 2007; 37 Calvo-Merino (10.1016/j.neulet.2013.09.044_bib0035) 2005; 15 Playford (10.1016/j.neulet.2013.09.044_bib0170) 1992; 32 Oldfield (10.1016/j.neulet.2013.09.044_bib0165) 1971; 9 Maravita (10.1016/j.neulet.2013.09.044_bib0145) 2004; 8 Nichols (10.1016/j.neulet.2013.09.044_bib0160) 2005; 25 Cameirao (10.1016/j.neulet.2013.09.044_bib0040) 2010; 7 Garrison (10.1016/j.neulet.2013.09.044_bib0100) 2010; 24 Singer (10.1016/j.neulet.2013.09.044_bib0195) 2004; 303 Vingerhoets (10.1016/j.neulet.2013.09.044_bib0200) 2010; 169 Gallese (10.1016/j.neulet.2013.09.044_bib0090) 1996; 119 Cabinio (10.1016/j.neulet.2013.09.044_bib0030) 2010; 51 Deiber (10.1016/j.neulet.2013.09.044_bib0060) 1996; 75 Logothetis (10.1016/j.neulet.2013.09.044_bib0140) 2003; 23 Sale (10.1016/j.neulet.2013.09.044_bib0185) 2012; 48 Farrer (10.1016/j.neulet.2013.09.044_bib0070) 2003; 18 Buccino (10.1016/j.neulet.2013.09.044_bib0015) 2001; 13 Frith (10.1016/j.neulet.2013.09.044_bib0085) 2000 Bucchioni (10.1016/j.neulet.2013.09.044_bib0010) 2013; 81 Di Dio (10.1016/j.neulet.2013.09.044_bib0065) 2013; 64 Newman-Norlund (10.1016/j.neulet.2013.09.044_bib0155) 2010; 1315 Gazzola (10.1016/j.neulet.2013.09.044_bib0105) 2009; 19 Gallese (10.1016/j.neulet.2013.09.044_bib0095) 2002; 19 Iacoboni (10.1016/j.neulet.2013.09.044_bib0130) 2005; 3 Gozli (10.1016/j.neulet.2013.09.044_bib0115) 2011; 40 Modroño (10.1016/j.neulet.2013.09.044_bib0150) 2011; 202 Prochnow (10.1016/j.neulet.2013.09.044_bib0175) 2013; 37 Buccino (10.1016/j.neulet.2013.09.044_bib0020) 2004; 16 Ferrari (10.1016/j.neulet.2013.09.044_bib0075) 2005; 17 Jenkins (10.1016/j.neulet.2013.09.044_bib0135) 2000; 123 Bischoff (10.1016/j.neulet.2013.09.044_bib0005) 2012; 50 Hoffman (10.1016/j.neulet.2013.09.044_bib0120) 2006; 11 David (10.1016/j.neulet.2013.09.044_bib0055) 2008; 17 Iacoboni (10.1016/j.neulet.2013.09.044_bib0125) 2004; 21 |
| References_xml | – volume: 19 start-page: 55 year: 2006 end-page: 63 ident: bib0025 article-title: Functions of the mirror neuron system: Implications for neurorehabilitation publication-title: Cognitive and Behavioral Neurology – volume: 15 start-page: 1243 year: 2005 end-page: 1249 ident: bib0035 article-title: Action observation and acquired motor skills: an fMRI study with expert dancers publication-title: Cerebral Cortex – volume: 19 start-page: 334 year: 2002 end-page: 355 ident: bib0095 article-title: Action representation and the inferior parietal lobule publication-title: Common Mechanisms in Perception and Action – volume: 48 start-page: 313 year: 2012 end-page: 318 ident: bib0185 article-title: Action observation and mirror neuron network: a tool for motor stroke rehabilitation publication-title: European Journal of Physical and Rehabilitation Medicine – volume: 303 start-page: 1157 year: 2004 end-page: 1162 ident: bib0195 article-title: Empathy for pain involves the affective but not sensory components of pain publication-title: Science – volume: 66 start-page: 557 year: 2009 end-page: 560 ident: bib0050 article-title: The Mirror Neuron System publication-title: Archives of Neurology – volume: 50 start-page: 2085 year: 2012 end-page: 2092 ident: bib0005 article-title: Motor familiarity: brain activation when watching kinematic displays of one's own movements publication-title: Neuropsychologia – volume: 19 start-page: 1239 year: 2009 end-page: 1255 ident: bib0105 article-title: The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fmri data publication-title: Cerebral Cortex – volume: 23 start-page: 3963 year: 2003 end-page: 3971 ident: bib0140 article-title: The underpinnings of the BOLD functional magnetic resonance imaging signal publication-title: Journal of Neuroscience – volume: 81 start-page: 176 year: 2013 end-page: 182 ident: bib0010 article-title: Corticospinal excitability during the observation of social behavior publication-title: Brain and Cognition – volume: 16 start-page: 114 year: 2004 end-page: 126 ident: bib0020 article-title: Neural circuits involved in the recognition of actions performed by nonconspecifics: an fMRI study publication-title: Journal of Cognitive Neuroscience – volume: 3 start-page: 529 year: 2005 end-page: 535 ident: bib0130 article-title: Grasping the intentions of others with one's own mirror neuron system publication-title: PLoS Biology – volume: 7 year: 2010 ident: bib0040 article-title: Neurorehabilitation using the virtual reality based Rehabilitation Gaming System: methodology, design, psychometrics, usability and validation publication-title: Journal of Neuroengineering and Rehabilitation – volume: 17 start-page: 523 year: 2008 end-page: 534 ident: bib0055 article-title: The “sense of agency” and its underlying cognitive and neural mechanisms publication-title: Consciousness and Cognition – volume: 8 start-page: 79 year: 2004 end-page: 86 ident: bib0145 article-title: Tools for the body (schema) publication-title: Trends in Cognitive Sciences – volume: 11 start-page: 45 year: 2006 end-page: 51 ident: bib0120 article-title: Using fMRI to study the neural correlates of virtual reality analgesia publication-title: CNS Spectrums – volume: 51 start-page: 313 year: 2010 end-page: 323 ident: bib0030 article-title: The shape of motor resonance: right- or left-handed? publication-title: Neuroimage – volume: 37 start-page: 1315 year: 2007 end-page: 1328 ident: bib0080 article-title: Human cortical representations for reaching: mirror neurons for execution, observation, and imagery publication-title: Neuroimage – volume: 169 start-page: 1158 year: 2010 end-page: 1167 ident: bib0200 article-title: Multifocal intraparietal activation during discrimination of action intention in observed tool grasping publication-title: Neuroscience – volume: 119 start-page: 593 year: 1996 end-page: 609 ident: bib0090 article-title: Action recognition in the premotor cortex publication-title: Brain – start-page: 393 year: 2007 end-page: 397 ident: bib0045 article-title: A virtual reality system for motor and cognitive neurorehabilitation publication-title: Challenges for Assistive Technology – start-page: 549 year: 2000 end-page: 565 ident: bib0085 article-title: The role of dorsolateral prefrontal cortex in the selection of action as revealed by functional imaging publication-title: Control of Cognitive Processes: Attention and Performance XVIII – volume: 64 start-page: 425 year: 2013 end-page: 436 ident: bib0065 article-title: The neural correlates of velocity processing during the observation of a biological effector in the parietal and premotor cortex publication-title: Neuroimage – volume: 17 start-page: 212 year: 2005 end-page: 226 ident: bib0075 article-title: Mirror neurons responding to observation of actions made with tools in monkey ventral premotor cortex publication-title: Journal of Cognitive Neuroscience – volume: 9 start-page: 97 year: 1971 end-page: 113 ident: bib0165 article-title: Assessment and analysis of handedness: the Edinburgh Inventory publication-title: Neuropsychologia – volume: 40 start-page: 1309 year: 2011 end-page: 1319 ident: bib0115 article-title: Agency and control for the integration of a virtual tool into the peripersonal space publication-title: Perception – volume: 35 start-page: 1674 year: 2007 end-page: 1684 ident: bib0110 article-title: The anthropomorphic brain: the mirror neuron system responds to human and robotic actions publication-title: Neuroimage – volume: 21 start-page: 1167 year: 2004 end-page: 1173 ident: bib0125 article-title: Watching social interactions produces dorsomedial prefrontal and medial parietal BOLD fMRI signal increases compared to a resting baseline publication-title: Neuroimage – volume: 18 start-page: 324 year: 2003 end-page: 333 ident: bib0070 article-title: Modulating the experience of agency: a positron emission tomography study publication-title: Neuroimage – volume: 9 start-page: 569 year: 2006 end-page: 577 ident: bib0190 article-title: Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1 publication-title: Nature Neuroscience – volume: 1315 start-page: 63 year: 2010 end-page: 74 ident: bib0155 article-title: The role of inferior frontal and parietal areas in differentiating meaningful and meaningless object-directed actions publication-title: Brain Research – volume: 75 start-page: 233 year: 1996 end-page: 247 ident: bib0060 article-title: Cerebral structures participating in motor preparation in humans: a positron emission tomography study publication-title: Journal of Neurophysiology – volume: 123 start-page: 1216 year: 2000 end-page: 1228 ident: bib0135 article-title: Self-initiated versus externally triggered movements II. The effect of movement predictability on regional cerebral blood flow publication-title: Brain – volume: 24 start-page: 404 year: 2010 end-page: 412 ident: bib0100 article-title: The Mirror Neuron System: a neural substrate for methods in stroke rehabilitation publication-title: Neurorehabilitation and Neural Repair – volume: 32 start-page: 151 year: 1992 end-page: 161 ident: bib0170 article-title: Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study publication-title: Annals of Neurology – volume: 13 start-page: 400 year: 2001 end-page: 404 ident: bib0015 article-title: Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study publication-title: European Journal of Neuroscience – volume: 202 start-page: 173 year: 2011 end-page: 181 ident: bib0150 article-title: A low cost fMRI-compatible tracking system using the Nintendo Wii remote publication-title: Journal of Neuroscience Methods – volume: 25 start-page: 653 year: 2005 end-page: 660 ident: bib0160 article-title: Valid conjunction inference with the minimum statistic publication-title: Neuroimage – volume: 37 start-page: 1441 year: 2013 end-page: 1447 ident: bib0175 article-title: A functional magnetic resonance imaging study of visuomotor processing in a virtual reality-based paradigm: Rehabilitation Gaming System publication-title: European Journal of Neuroscience – volume: 50 start-page: 1639 year: 2010 end-page: 1647 ident: bib0180 article-title: Live face-to-face interaction during fMRI: A new tool for social cognitive neuroscience publication-title: Neuroimage – volume: 19 start-page: 334 year: 2002 ident: 10.1016/j.neulet.2013.09.044_bib0095 article-title: Action representation and the inferior parietal lobule publication-title: Common Mechanisms in Perception and Action doi: 10.1093/oso/9780198510697.003.0017 – volume: 13 start-page: 400 year: 2001 ident: 10.1016/j.neulet.2013.09.044_bib0015 article-title: Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study publication-title: European Journal of Neuroscience doi: 10.1111/j.1460-9568.2001.01385.x – volume: 35 start-page: 1674 year: 2007 ident: 10.1016/j.neulet.2013.09.044_bib0110 article-title: The anthropomorphic brain: the mirror neuron system responds to human and robotic actions publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.02.003 – volume: 9 start-page: 97 year: 1971 ident: 10.1016/j.neulet.2013.09.044_bib0165 article-title: Assessment and analysis of handedness: the Edinburgh Inventory publication-title: Neuropsychologia doi: 10.1016/0028-3932(71)90067-4 – volume: 303 start-page: 1157 year: 2004 ident: 10.1016/j.neulet.2013.09.044_bib0195 article-title: Empathy for pain involves the affective but not sensory components of pain publication-title: Science doi: 10.1126/science.1093535 – start-page: 549 year: 2000 ident: 10.1016/j.neulet.2013.09.044_bib0085 article-title: The role of dorsolateral prefrontal cortex in the selection of action as revealed by functional imaging – volume: 15 start-page: 1243 year: 2005 ident: 10.1016/j.neulet.2013.09.044_bib0035 article-title: Action observation and acquired motor skills: an fMRI study with expert dancers publication-title: Cerebral Cortex doi: 10.1093/cercor/bhi007 – volume: 19 start-page: 1239 year: 2009 ident: 10.1016/j.neulet.2013.09.044_bib0105 article-title: The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fmri data publication-title: Cerebral Cortex doi: 10.1093/cercor/bhn181 – volume: 119 start-page: 593 year: 1996 ident: 10.1016/j.neulet.2013.09.044_bib0090 article-title: Action recognition in the premotor cortex publication-title: Brain doi: 10.1093/brain/119.2.593 – volume: 16 start-page: 114 year: 2004 ident: 10.1016/j.neulet.2013.09.044_bib0020 article-title: Neural circuits involved in the recognition of actions performed by nonconspecifics: an fMRI study publication-title: Journal of Cognitive Neuroscience doi: 10.1162/089892904322755601 – volume: 40 start-page: 1309 year: 2011 ident: 10.1016/j.neulet.2013.09.044_bib0115 article-title: Agency and control for the integration of a virtual tool into the peripersonal space publication-title: Perception doi: 10.1068/p7027 – volume: 8 start-page: 79 year: 2004 ident: 10.1016/j.neulet.2013.09.044_bib0145 article-title: Tools for the body (schema) publication-title: Trends in Cognitive Sciences doi: 10.1016/j.tics.2003.12.008 – volume: 75 start-page: 233 year: 1996 ident: 10.1016/j.neulet.2013.09.044_bib0060 article-title: Cerebral structures participating in motor preparation in humans: a positron emission tomography study publication-title: Journal of Neurophysiology doi: 10.1152/jn.1996.75.1.233 – volume: 48 start-page: 313 year: 2012 ident: 10.1016/j.neulet.2013.09.044_bib0185 article-title: Action observation and mirror neuron network: a tool for motor stroke rehabilitation publication-title: European Journal of Physical and Rehabilitation Medicine – volume: 17 start-page: 523 year: 2008 ident: 10.1016/j.neulet.2013.09.044_bib0055 article-title: The “sense of agency” and its underlying cognitive and neural mechanisms publication-title: Consciousness and Cognition doi: 10.1016/j.concog.2008.03.004 – volume: 3 start-page: 529 year: 2005 ident: 10.1016/j.neulet.2013.09.044_bib0130 article-title: Grasping the intentions of others with one's own mirror neuron system publication-title: PLoS Biology doi: 10.1371/journal.pbio.0030079 – volume: 17 start-page: 212 year: 2005 ident: 10.1016/j.neulet.2013.09.044_bib0075 article-title: Mirror neurons responding to observation of actions made with tools in monkey ventral premotor cortex publication-title: Journal of Cognitive Neuroscience doi: 10.1162/0898929053124910 – volume: 24 start-page: 404 year: 2010 ident: 10.1016/j.neulet.2013.09.044_bib0100 article-title: The Mirror Neuron System: a neural substrate for methods in stroke rehabilitation publication-title: Neurorehabilitation and Neural Repair doi: 10.1177/1545968309354536 – volume: 202 start-page: 173 year: 2011 ident: 10.1016/j.neulet.2013.09.044_bib0150 article-title: A low cost fMRI-compatible tracking system using the Nintendo Wii remote publication-title: Journal of Neuroscience Methods doi: 10.1016/j.jneumeth.2011.05.014 – volume: 81 start-page: 176 year: 2013 ident: 10.1016/j.neulet.2013.09.044_bib0010 article-title: Corticospinal excitability during the observation of social behavior publication-title: Brain and Cognition doi: 10.1016/j.bandc.2012.11.001 – volume: 1315 start-page: 63 year: 2010 ident: 10.1016/j.neulet.2013.09.044_bib0155 article-title: The role of inferior frontal and parietal areas in differentiating meaningful and meaningless object-directed actions publication-title: Brain Research doi: 10.1016/j.brainres.2009.11.065 – volume: 66 start-page: 557 year: 2009 ident: 10.1016/j.neulet.2013.09.044_bib0050 article-title: The Mirror Neuron System publication-title: Archives of Neurology doi: 10.1001/archneurol.2009.41 – volume: 19 start-page: 55 year: 2006 ident: 10.1016/j.neulet.2013.09.044_bib0025 article-title: Functions of the mirror neuron system: Implications for neurorehabilitation publication-title: Cognitive and Behavioral Neurology doi: 10.1097/00146965-200603000-00007 – volume: 21 start-page: 1167 year: 2004 ident: 10.1016/j.neulet.2013.09.044_bib0125 article-title: Watching social interactions produces dorsomedial prefrontal and medial parietal BOLD fMRI signal increases compared to a resting baseline publication-title: Neuroimage doi: 10.1016/j.neuroimage.2003.11.013 – volume: 64 start-page: 425 year: 2013 ident: 10.1016/j.neulet.2013.09.044_bib0065 article-title: The neural correlates of velocity processing during the observation of a biological effector in the parietal and premotor cortex publication-title: Neuroimage doi: 10.1016/j.neuroimage.2012.09.026 – volume: 18 start-page: 324 year: 2003 ident: 10.1016/j.neulet.2013.09.044_bib0070 article-title: Modulating the experience of agency: a positron emission tomography study publication-title: Neuroimage doi: 10.1016/S1053-8119(02)00041-1 – volume: 37 start-page: 1441 year: 2013 ident: 10.1016/j.neulet.2013.09.044_bib0175 article-title: A functional magnetic resonance imaging study of visuomotor processing in a virtual reality-based paradigm: Rehabilitation Gaming System publication-title: European Journal of Neuroscience doi: 10.1111/ejn.12157 – volume: 51 start-page: 313 year: 2010 ident: 10.1016/j.neulet.2013.09.044_bib0030 article-title: The shape of motor resonance: right- or left-handed? publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.01.103 – volume: 50 start-page: 1639 year: 2010 ident: 10.1016/j.neulet.2013.09.044_bib0180 article-title: Live face-to-face interaction during fMRI: A new tool for social cognitive neuroscience publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.01.052 – volume: 32 start-page: 151 year: 1992 ident: 10.1016/j.neulet.2013.09.044_bib0170 article-title: Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study publication-title: Annals of Neurology doi: 10.1002/ana.410320206 – volume: 50 start-page: 2085 year: 2012 ident: 10.1016/j.neulet.2013.09.044_bib0005 article-title: Motor familiarity: brain activation when watching kinematic displays of one's own movements publication-title: Neuropsychologia doi: 10.1016/j.neuropsychologia.2012.05.009 – volume: 169 start-page: 1158 year: 2010 ident: 10.1016/j.neulet.2013.09.044_bib0200 article-title: Multifocal intraparietal activation during discrimination of action intention in observed tool grasping publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.05.080 – volume: 9 start-page: 569 year: 2006 ident: 10.1016/j.neulet.2013.09.044_bib0190 article-title: Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1 publication-title: Nature Neuroscience doi: 10.1038/nn1675 – start-page: 393 year: 2007 ident: 10.1016/j.neulet.2013.09.044_bib0045 article-title: A virtual reality system for motor and cognitive neurorehabilitation – volume: 11 start-page: 45 year: 2006 ident: 10.1016/j.neulet.2013.09.044_bib0120 article-title: Using fMRI to study the neural correlates of virtual reality analgesia publication-title: CNS Spectrums doi: 10.1017/S1092852900024202 – volume: 7 year: 2010 ident: 10.1016/j.neulet.2013.09.044_bib0040 article-title: Neurorehabilitation using the virtual reality based Rehabilitation Gaming System: methodology, design, psychometrics, usability and validation publication-title: Journal of Neuroengineering and Rehabilitation doi: 10.1186/1743-0003-7-48 – volume: 23 start-page: 3963 year: 2003 ident: 10.1016/j.neulet.2013.09.044_bib0140 article-title: The underpinnings of the BOLD functional magnetic resonance imaging signal publication-title: Journal of Neuroscience doi: 10.1523/JNEUROSCI.23-10-03963.2003 – volume: 25 start-page: 653 year: 2005 ident: 10.1016/j.neulet.2013.09.044_bib0160 article-title: Valid conjunction inference with the minimum statistic publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.12.005 – volume: 123 start-page: 1216 year: 2000 ident: 10.1016/j.neulet.2013.09.044_bib0135 article-title: Self-initiated versus externally triggered movements II. The effect of movement predictability on regional cerebral blood flow publication-title: Brain doi: 10.1093/brain/123.6.1216 – volume: 37 start-page: 1315 year: 2007 ident: 10.1016/j.neulet.2013.09.044_bib0080 article-title: Human cortical representations for reaching: mirror neurons for execution, observation, and imagery publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.06.008 |
| SSID | ssj0005154 |
| Score | 2.1694527 |
| Snippet | •Subjects manipulated virtual tools in a digital game and watched the replays.•Virtual limbs were not necessary to produce extended mirror activity.•M1 showed... This work explores the mirror neuron system activity produced by the observation of virtual tool manipulations in the absence of a visible effector limb.... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 220 |
| SubjectTerms | Adolescent Adult Brain Mapping Female fMRI Functional Laterality Humans Magnetic Resonance Imaging Male Mirror neurons Mirror Neurons - physiology Neurorehabilitation Psychomotor Performance Tool use User-Computer Interface Video Games Virtual reality Visual Perception Young Adult |
| Title | Activation of the human mirror neuron system during the observation of the manipulation of virtual tools in the absence of a visible effector limb |
| URI | https://dx.doi.org/10.1016/j.neulet.2013.09.044 https://www.ncbi.nlm.nih.gov/pubmed/24080372 https://www.proquest.com/docview/1459150214 https://www.proquest.com/docview/1516751923 |
| Volume | 555 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3LatwwUIQUSi-lTfrYpgkqlN7cta2nj0to2LYklzaQm5FkGVx27eDsFnrpR_SLMyNZS3NIAz1aHtliZqSZ0bwIee-ADRRzKhOqMBk3VZtVrG0y7pUWxnElLCY4n1_I5SX_ciWu9shpyoXBsMrp7I9nejitp5H5hM35ddfNv6FTD_t6o0NGS41JfJwr5PKPv_8K8yhELCGFHgCATulzIcar91vADgZ4sVDtlPP7xNN96mcQQ2fPyNNJf6SLuMTnZM_3B-Rw0YPtvP5FP9AQ0Rmuyg_I4_PJcX5I_ixc6mNGh5aC1kdDdz667sZxGGkoa9nTWNeZxtzFADXY3bVtmogVM1LXLxz72Y2YhEI3w7C6oV0fgAzMA1zie0Mxgd2uPI3BI_C7Vbe2L8jl2afvp8tsaseQOVaJTSZlA_g0jhnmteFN6Rvlc2EbbVuQ82B5icprJivRFo01vqka2basMcp70Gpy9pLs90PvXxMqXelAD7JSu5Jr5k2u4HN4P-2k1KKcEZaoULupVjm2zFjVKSjtRx1pVyPt6ryqgXYzku1mXcdaHQ_Aq0Tg-g7P1SBOHpj5LvFDDdsRfSym98P2BiwpUYGOXRb_ghEFmGmoWs_Iq8hMu_VixbmcqfLNf6_tiDzBJ5SvpXhL9jfj1h-D4rSxJ2FnnJBHi89flxe3EHUabw |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3LbtQw0CpFAi4IWh7L00iIW9gkjh85rqpWC3R7oZV6s2zHkVLtJlW6i8SFj-gXd8ZOVnBoK3G1ZxJrZuwZe16EfHYgBpI5mXCZmaQwZZ2UrK6SwkvFjSskt5jgvDgR87Pi-zk_3yEHYy4MhlUOZ38808NpPYxMB2pOL5tm-hOdetjXGx0ySqjyAXlYwPbFNgZf__wV55HxWEMKXQAAPubPhSCv1m-APBjhxUK506K4TT_dZn8GPXT0jDwdDEg6i2t8TnZ8u0f2Zy1cnle_6RcaQjrDW_keebQYPOf75HrmxkZmtKspmH00tOejq6bvu56GupYtjYWdaUxeDFCd3b7bjohYMmNs-4Vjv5oes1DouuuWV7RpA5ABPCAmzhuKGex26WmMHoHfLZuVfUHOjg5PD-bJ0I8hcazk60SICuhpHDPMK1NUua-kT7mtlK1B0cPVi5deMVHyOqus8VVZibpmlZHeg1mTspdkt-1a_5pQ4XIHhpAVyuWFYt6kEj6HD9ROCMXzCWEjF7QbipVjz4ylHqPSLnTknUbe6bTUwLsJSbZYl7FYxz3wcmSw_kfoNOiTezA_jfKgYT-ik8W0vttcwVWKl2Bk59ldMDyDexra1hPyKgrTdr1Yci5lMn_z32v7SB7PTxfH-vjbyY-35AnOoLLN-Tuyu-43_j1YUWv7IeySG1KRG_0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Activation+of+the+human+mirror+neuron+system+during+the+observation+of+the+manipulation+of+virtual+tools+in+the+absence+of+a+visible+effector+limb&rft.jtitle=Neuroscience+letters&rft.au=Modro%C3%B1o%2C+Cristi%C3%A1n&rft.au=Navarrete%2C+Gorka&rft.au=Rodr%C3%ADguez-Hern%C3%A1ndez%2C+Antonio+F.&rft.au=Gonz%C3%A1lez-Mora%2C+Jos%C3%A9+L.&rft.date=2013-10-25&rft.issn=0304-3940&rft.volume=555&rft.spage=220&rft.epage=224&rft_id=info:doi/10.1016%2Fj.neulet.2013.09.044&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_neulet_2013_09_044 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-3940&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-3940&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-3940&client=summon |