Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy

• Published in: Biochimica et biophysica acta Vol. 1830; no. 6; pp. 3776 - 3786
• Main Authors: Yadav, Sudhir K., Adhikary, Biplab, Bandyopadhyay, Sandip K., Chattopadhyay, Subrata
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2013
• Subjects: adhesion; adverse effects; Angiogenesis; Animals; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; anti-ulcer activity; Anti-Ulcer Agents - pharmacology; antioxidant activity; antioxidants; Catechols - chemistry; Catechols - pharmacology; Disease Models, Animal; enzyme-linked immunosorbent assay; Gastric ulcer; growth factors; histology; Indomethacin; Indomethacin - adverse effects; Indomethacin - pharmacology; Inflammatory modulator; Male; MAP Kinase Signaling System - drug effects; messenger RNA; Mice; Misoprostol - pharmacology; mitogen-activated protein kinase; nonsteroidal anti-inflammatory agents; NSAID; Omeprazole - pharmacology; oxidative stress; Oxidative Stress - drug effects; pharmacokinetics; Piper betle - chemistry; prostaglandins; receptors; Stomach Ulcer - chemically induced; Stomach Ulcer - drug therapy; Stomach Ulcer - metabolism; Stomach Ulcer - pathology; transcription factor NF-kappa B; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Angiogenesis; Inflammatory modulator; Indomethacin; Gastric ulcer; NSAID

The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistically. Mice were pre-treated with APC for 1h followed...