Histone code of genes induced by co-treatment with a glucocorticoid hormone agonist and a p44/42 MAPK inhibitor in human small intestinal Caco-2 cells

• Published in: Biochimica et biophysica acta Vol. 1840; no. 1; pp. 693 - 700
• Main Authors: Inamochi, Yuko, Mochizuki, Kazuki, Goda, Toshinao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2014
• Subjects: Acetylation; agonists; Antineoplastic Agents, Hormonal - pharmacology; Biomarkers - metabolism; Caco-2 Cells; Chromatin Immunoprecipitation; dexamethasone; Dexamethasone - pharmacology; Differentiation; Flavonoids - pharmacology; gene expression; Gene Expression Profiling; genes; Glucocorticoid hormone; Histone code; Histone Code - drug effects; Histone Code - genetics; histones; hormones; human cell lines; Humans; lysine; methylation; microarray technology; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors; Mitogen-Activated Protein Kinase 3 - metabolism; Oligonucleotide Array Sequence Analysis; p44/42 MAPK; Promoter Regions, Genetic; Protein Kinase Inhibitors - pharmacology; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Caco-2 cells; Differentiation; p44/42 MAPK; Histone code; Glucocorticoid hormone

Inactivation of glucocorticoid hormones and p44/42 mitogen-activated protein kinase (MAPK) is thought to be important in small intestinal maturation and expression of genes related to intestinal differentiation and functions. We investigated target genes induced by co-treatment for 48h with a glucoc...