Hemin-utilizing G-quadruplex DNAzymes are strongly active in organic co-solvents

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1455 - 1462
• Main Authors: Canale, Thomas D., Sen, Dipankar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: Binding Sites; Catalysis; catalysts; catalytic activity; Circular Dichroism; dimethylformamide; Dimethylformamide - chemistry; DNA; DNA, Catalytic - chemistry; DNA, Catalytic - metabolism; DNAzyme; Enzyme Activation; enzyme activity; Formamides - chemistry; G-quadruplex; G-Quadruplexes; Guanosine - chemistry; Guanosine - metabolism; Heme; Hemin - chemistry; Hemin - metabolism; iron; Ligands; methanol; Methanol - chemistry; Oligonucleotides - chemistry; Oligonucleotides - metabolism; Organic Chemicals - chemistry; Organic solvents; Oxidation; Oxidation-Reduction; peroxidase; Protein Binding; solvents; Solvents - chemistry; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; tert-Butyl Alcohol - chemistry; Water - chemistry; DNAzyme; Oxidation; Organic solvents; G-quadruplex; Heme

The widespread use of organic solvents in industrial processes has focused in recent years on the utility of “green” solvents – those with less harmful environmental, health, and safety properties – such as methanol and formamide. However, protein enzymes, regarded as green catalysts, are often inco...