Ginsenoside Rd: A promising natural neuroprotective agent

• Published in: Phytomedicine (Stuttgart) Vol. 95; p. 153883
• Main Authors: Chen, Yu-Ying, Liu, Qiu-Ping, An, Pei, Jia, Min, Luan, Xin, Tang, Jian-Yuan, Zhang, Hong
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.01.2022
• Subjects: active ingredients; adverse effects; Alzheimer disease; antioxidants; calcium; China; cognitive disorders; Ginsenoside Rd; ginsenosides; Ginsenosides - pharmacology; herbal medicines; human health; Humans; Mechanism; mitochondria; nerve growth factor; nerve tissue; Neuroprotection; Neuroprotective Agents - pharmacology; Panax; Panax ginseng; Parkinson disease; Phytotherapy; Signal pathway; toxicity; China; APP; Ginsenoside Rd; Erα; JNK; S100-β; MDA; Panax ginseng; Caspase-3; MyD88; Aβ; PI3K; GAP-43; iNOS; NFT; AIF; AD; PKC; IL-1β; NGF; PP-2A; IRAK; MMP; NSCs; CAT; NF-kβ; ROS; NMDAR; CytoC; ERK; NADPH; Neuroprotection; Signal pathway; COX-2; CRS; PPD; CNS; Mechanism; GSK-3β; OA; Rd; TCMs; CREB; PPT; IκK; GSSG; PGE2; GSH-Px; BDNF; OT; SOD; TrkB; NFTs; PD; TNF-α; TH; Bax; TMT; HD

Neurological diseases seriously affect human health, which are arousing wider attention, and it is a great challenge to discover neuroprotective drugs with minimal side-effects and better efficacies. Natural agents derived from herbs or plants have become unparalleled resources for the discovery of...