Ultrastructural aspects of melatonin cytotoxicity on Caco-2 cells in vitro

• Published in: Micron (Oxford, England : 1993) Vol. 59; pp. 17 - 23
• Main Authors: Batista, Ana Paula C., da Silva, Terezinha G., Teixeira, Álvaro A.C., de Medeiros, Paloma L., Teixeira, Valeria W., Alves, Luiz C., dos Santos, Fábio A.B., Silva, Eliete C.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2014
• Subjects: Adenocarcinoma; Apoptosis - drug effects; Caco-2; Caco-2 Cells - drug effects; Caco-2 Cells - ultrastructure; Colon; Colorimetry; Cytotoxicity; Degeneration; Effectiveness; Humans; In vitro testing; In vivo methods and tests; Melatonin; Melatonin - pharmacology; Microscopy, Electron, Transmission; Mitochondria - drug effects; Mitochondria - metabolism; Reactive Oxygen Species - metabolism; Tumors; Ultrastructure; Adenocarcinoma; Cytotoxicity; Melatonin; Ultrastructure; Caco-2

Colon adenocarcinoma is a disease expanding worldwide. Cancer of colon and rectum are among the top ten most insidious types in Brazil. In vitro and in vivo studies have demonstrated the efficacy of the hormone melatonin to prevent and reduce tumor growth. However, there are only few studies address...