High-resolution atomic force microscopy visualization of metalloproteins and their complexes

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 12; pp. 2862 - 2868
• Main Authors: Barinov, Nikolay A., Vlasova, Irina I., Sokolov, Alexey V., Kostevich, Valeria A., Dubrovin, Evgeniy V., Klinov, Dmitry V.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2018
• Subjects: anti-inflammatory agents; atomic force microscopy; Ceruloplasmin; Ceruloplasmin - chemistry; Ceruloplasmin - ultrastructure; Coordination Complexes - chemistry; ferroxidase; graphene; Graphite - chemistry; High-resolution atomic force microscopy; Humans; inflammation; Lactoferrin; Lactoferrin - chemistry; Lactoferrin - ultrastructure; Metalloprotein complexes; metalloproteins; Microscopy, Atomic Force - methods; Molecular Structure; Myeloperoxidase; Oxidation stress; Oxidative Stress; Peroxidase - chemistry; Peroxidase - ultrastructure; Surface Properties; ultrastructure; vertebrates; Ceruloplasmin; Myeloperoxidase; Lactoferrin; High-resolution atomic force microscopy; Metalloprotein complexes; Oxidation stress

Metalloproteins myeloperoxidase (MPO), ceruloplasmin (CP) and lactoferrin (LF) play an important role in regulation of inflammation and oxidative stress in vertebrates. It was previously shown that these proteins may work synergetically as antimicrobial and anti-inflammatory agents by forming comple...