Peroxiredoxins as biomarkers of oxidative stress

• Published in: Biochimica et biophysica acta Vol. 1840; no. 2; pp. 906 - 912
• Main Authors: Poynton, Rebecca A., Hampton, Mark B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2014
• Subjects: Animals; Biomarker; biomarkers; Biomarkers - analysis; Biomarkers - metabolism; biophysics; homeostasis; Humans; Hydrogen peroxide; hydroperoxides; Hyperoxidation; membrane proteins; Oxidation; Oxidative Stress; peroxidases; Peroxiredoxin; Peroxiredoxins - analysis; Peroxiredoxins - metabolism; thiols; tissues; Peroxiredoxin; Oxidative stress; Biomarker; Hydrogen peroxide; IAM; AMS; NEM; Prx; Srx; Oxidation; Hyperoxidation; Cys; N-ethylmaleimide; cysteine; sulfiredoxin; 4′-4-acetamido-4′-((iodoacetyl)amino)stilbene-2,2′-disulfonic acid; iodoacetamide

Peroxiredoxins (Prxs) are a class of abundant thiol peroxidases that degrade hydroperoxides to water. Prxs are sensitive to oxidation, and it is hypothesized that they also act as redox sensors. The accumulation of oxidized Prxs may indicate disruption of cellular redox homeostasis. This review disc...