Altered ubiquitin-proteasome system leads to neuronal cell death in a spontaneous obese rat model

• Published in: Biochimica et biophysica acta Vol. 1840; no. 9; pp. 2924 - 2934
• Main Authors: Reddy, S. Sreenivasa, Shruthi, Karnam, Reddy, V. Sudhakar, Raghu, G., Suryanarayana, P., Giridharan, N.V., Reddy, G. Bhanuprakash
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2014
• Subjects: animal models; Animals; Apoptosis; axons; Brain; cerebral cortex; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Dietary Fats - adverse effects; Dietary Fats - pharmacology; Disease Models, Animal; Endoplasmic Reticulum Stress; fluorometry; immunoblotting; immunohistochemistry; mitochondria; Nerve Tissue Proteins - metabolism; neurodegenerative diseases; Neurons - metabolism; Neurons - pathology; Obesity; Obesity - chemically induced; Obesity - metabolism; Obesity - pathology; Proteasome; proteasome endopeptidase complex; Proteasome Endopeptidase Complex - metabolism; quantitative polymerase chain reaction; Rats; reverse transcriptase polymerase chain reaction; risk; transmission electron microscopy; Tumor Suppressor Protein p53 - metabolism; ubiquitin; Ubiquitin - metabolism; Ubiquitin C-terminal hydrolase; Ubiquitin Thiolesterase - metabolism; ultrastructure; DUB; Obesity; Brain; TUNEL; UPR; ER stress; UPS; UCH; Ubiquitin C-terminal hydrolase; Endoplasmic reticulum stress; Proteasome; Apoptosis

Obesity is associated with various progressive age-related diseases, including neurological disorders. However, underlying molecular basis for increased risk of neurodegeneration in obesity is unknown. A suitable animal model would immensely help in understanding the obesity-linked neurological prob...