The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions

• Published in: Neurochemistry international Vol. 62; no. 4; pp. 367 - 378
• Main Authors: Tiiman, Ann, Palumaa, Peep, Tõugu, Vello
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2013
• Subjects: Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid - metabolism; Amyloid beta; Homeostasis; Humans; Metal ions; Metals - metabolism; Aβ; APP; CFS; ThT; AD; BBB; Amyloid beta; Alzheimer’s disease; APOE; NFT; CQ; Metal ions

[Display omitted] ► Binding of Zn(II) and Cu(II) to Aβ has a complex effect on Aβ fibrillization. ► Amyloid cascade in AD may be triggered by metal (zinc and/or copper) ions. ► The toxicity of amyloid fibrils is caused by the content of redox-active metal ions. Progressive deposition of amyloid beta...