Cold-inducible RNA-binding protein mediates airway inflammation and mucus hypersecretion through a post-transcriptional regulatory mechanism under cold stress

• Published in: The international journal of biochemistry & cell biology Vol. 78; pp. 335 - 348
• Main Authors: Juan, Yang, Haiqiao, Wu, Xie, Wenyao, Huaping, Huang, Zhong, Han, Xiangdong, Zhou, Kolosov, Victor P., Perelman, Juliy M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2016
• Subjects: 3' Untranslated Regions - genetics; 3⿲-UTR; adenosine; Aged; Animals; arginine; asthma; breathing; Bronchitis - genetics; Bronchitis - metabolism; Bronchitis - physiopathology; cigarettes; cold; cold shock proteins; cold shock response; Cold stress; Cold-inducible RNA-binding protein; Cold-Shock Response - drug effects; cytokines; Cytokines - genetics; cytoplasm; enzyme inhibitors; Female; Gene Expression Regulation - drug effects; genes; Humans; hypersecretion; hypothermia; hypoxia; inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - physiopathology; Lung - drug effects; Lung - metabolism; Male; messenger RNA; methylation; Methylation - drug effects; methyltransferases; Middle Aged; mRNA stability; MUC5AC; Mucin 5AC - biosynthesis; mucus; Mucus - metabolism; Nicotiana - chemistry; patients; Post-translational; Pro-inflammatory cytokine; Protein Transport - drug effects; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - physiopathology; Rats; RNA-binding proteins; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Smoke - adverse effects; Transcription, Genetic - drug effects; translation (genetics); Up-Regulation - drug effects; Pro-inflammatory cytokine; Cold stress; Cold-inducible RNA-binding protein; 3⿲-UTR; Post-translational; MUC5AC; mRNA stability; 3′-UTR

Acute or chronic cold exposure exacerbates chronic inflammatory airway diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein and is induced by various environmental stressors, such as hypothermia and hypoxia. In t...