Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA - Monti, Alessandra; Sturlese, Mattia; Caporale, Andrea; Roger, Jessica De Almeida; Mascanzoni, Fabiola; Ruvo, Menotti; Doti, Nunzianna (Biochimica et biophysica acta. General subjects, 2020)
Keywords: AIF(370–394) stapled peptide; AIF/CypA complex; apoptosis; Apoptosis Inducing Factor - chemistry; Apoptosis Inducing Factor - metabolism; calorimetry; chromatin; Circular dichroism (CD); circular dichroism spectroscopy; Click chemistry; cyclophilin A; Cyclophilin A - metabolism; disulfides; DNA; Drug Design; Enspire label free; Humans; Isothermal Titration Calorimetry (ITC); Ligands; Molecular Docking Simulation; neurodegenerative diseases; neurons; Neuroprotective Agents - chemical synthesis; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; neuroprotective effect; NMR and molecular modeling analysis; nuclear magnetic resonance spectroscopy; peptides; Peptides - chemical synthesis; Peptides - chemistry; Peptides - pharmacology; therapeutics; thermodynamics; titration; Enspire label free; Circular dichroism (CD); AIF/CypA complex; Click chemistry; Isothermal Titration Calorimetry (ITC); NMR and molecular modeling analysis; AIF(370–394) stapled peptide