SWATH analysis of the synaptic proteome in Alzheimer's disease

• Published in: Neurochemistry international Vol. 87; pp. 1 - 12
• Main Authors: Chang, Rachel Yoon Kyung, Etheridge, Naomi, Nouwens, Amanda S., Dodd, Peter R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2015
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Cellular assembly and organization; Cerebral cortex; Female; HPLC; Human; Humans; Male; Nerve Tissue Proteins - metabolism; Pathway analysis; Proteome; Proteomics; Synapses - metabolism; Human; Pathway analysis; Cellular assembly and organization; Cerebral cortex; HPLC; Proteomics

•Combined SWATH and SCX were used to study synaptic proteomes in Alzheimer's disease.•A total of 2077 unique proteins were identified in synaptosomal fractions.•Thirty proteins, 17 of them novel, were differentially regulated in AD hippocampus.•Cellular assembly and organization were the most-p...