Structure, function, aging and turnover of aggrecan in the intervertebral disc

• Published in: Biochimica et biophysica acta Vol. 1840; no. 10; pp. 3181 - 3189
• Main Authors: Sivan, Sarit Sara, Wachtel, Ellen, Roughley, Peter
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2014
• Subjects: Aggrecan; Aggrecans - metabolism; Aging - metabolism; Aging - pathology; Animals; Biomimetics; Degeneration; glycation; Humans; hyaluronic acid; Intervertebral disc; Intervertebral Disc - metabolism; Intervertebral Disc - pathology; Intervertebral Disc Degeneration - metabolism; Intervertebral Disc Degeneration - pathology; intervertebral disks; metalloproteinases; proteoglycans; proteolysis; Repair; scientists; Structure-Activity Relationship; Turnover; CRP; NP; TNFα; ADAMTS; Biomimetics; Intervertebral disc; HYALs; Turnover; Degeneration; Repair; Asp; CML; EGF; AF; IGD; MMPs; KS; OSM; AGEs; CEL; GAG; BMP7; GDF5; ECM; IL1; CS; IVD; TGFβ; HA; Aggrecan

Aggrecan is the major non-collagenous component of the intervertebral disc. It is a large proteoglycan possessing numerous glycosaminoglycan chains and the ability to form aggregates in association with hyaluronan. Its abundance and unique molecular features provide the disc with its osmotic propert...