Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 2; pp. 23 - 36
• Main Authors: Rahman, Md. Ataur, Bishayee, Kausik, Sadra, Ali, Huh, Sung-Oh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2017
• Subjects: Animals; antioxidants; apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - metabolism; autophagy; Autophagy - drug effects; Caspase 3 - metabolism; caspase-3; Caspase-independent; cell cycle; Cell Line; Cell Line, Tumor; Cell Survival - drug effects; cell viability; cytotoxicity; dose response; drug resistance; HEK293 Cells; Humans; immunocytochemistry; Macroautophagy; membrane potential; mitochondrial membrane; mitogen-activated protein kinase; mTOR signaling; neoplasms; Neuroblastoma; Neuroblastoma - drug therapy; Neuroblastoma - metabolism; Oxyresveratrol; p38 MAPK; p38 Mitogen-Activated Protein Kinases - metabolism; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation - drug effects; Plant Extracts - pharmacology; protein synthesis; proteins; Proto-Oncogene Proteins c-akt - metabolism; Rats; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; small interfering RNA; Stilbenes - pharmacology; TOR Serine-Threonine Kinases - metabolism; Tumor Suppressor Protein p53 - metabolism; Western blotting; Oxyresveratrol; Caspase-independent; Neuroblastoma; mTOR signaling; Macroautophagy; p38 MAPK

Drug resistance from apoptosis is a challenging issue with different cancer types, and there is an interest in identifying other means of inducing cytotoxicity. Here, treatment of neuroblastoma cells with oxyresveratrol (OXYRES), a natural antioxidant, led to dose-dependent cell death and increased...