Determination of number-average aggregation numbers of bile salts micelles with a special emphasis on their oxo derivatives—The effect of the steroid skeleton

• Published in: Biochimica et biophysica acta Vol. 1840; no. 3; pp. 1072 - 1082
• Main Authors: Poša, Mihalj, Sebenji, Ana
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2014
• Subjects: aggregation number; anions; Bile Acids and Salts - chemistry; bile salts; cholic acid; conformational analysis; geometry; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; hydrophobic bonding; hydrophobicity; linear models; Magnetic Resonance Spectroscopy; micelle of bile salt; Micelles; Molecular Conformation; regression analysis; sodium; spin–lattice relaxation time; steroid skeleton; steroids; Steroids - chemistry; thermodynamics; steroid skeleton; conformational analysis; micelle of bile salt; spin–lattice relaxation time; aggregation number
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/j.bbagen.2013.11.008

The special geometry of the steroid skeleton causes that bile acid anions, in contrast to aliphatic amphiphiles, form micelles with a small aggregation number. The number-average aggregation numbers (n¯) are determined using Moroi–Matsuoka–Sugioka thermodynamic method. Also, for analysed bile acid s...