Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation

• Published in: The Journal of immunology (1950) Vol. 183; no. 11; pp. 6903 - 6912
• Main Authors: Garcia-Bates, Tatiana M, Baglole, Carolyn J, Bernard, Matthew P, Murant, Thomas I, Simpson-Haidaris, Patricia J, Phipps, Richard P
• Format: Journal Article
• Language: English
• Published: United States 01.12.2009
• Subjects: Antibody Formation - immunology; B-Lymphocytes - cytology; B-Lymphocytes - immunology; Blotting, Western; Cell Differentiation - immunology; Cell Proliferation; Cyclooxygenase 2 - biosynthesis; Cyclooxygenase 2 - immunology; Flow Cytometry; Gene Expression - immunology; Gene Expression Regulation - immunology; Humans; Ligands; Lymphocyte Activation - immunology; Positive Regulatory Domain I-Binding Factor 1; PPAR gamma - biosynthesis; PPAR gamma - immunology; Repressor Proteins - biosynthesis; Repressor Proteins - immunology; Retinoid X Receptor alpha - biosynthesis; Retinoid X Receptor alpha - immunology; Transfection; Up-Regulation

Protective humoral immune responses critically depend on the optimal differentiation of B cells into Ab-secreting cells. Because of the important role of Abs in fighting infections and in successful vaccination, it is imperative to identify mediators that control B cell differentiation. Activation o...