Semysinthetic biflavonoid Morelloflavone-7,4′,7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 12; p. 130016
• Main Authors: de Souza, Aline Aparecida, de Andrade, Débora Martins, Siqueira, Fábio da Silva, Di Iorio, Juliana Fortes, Veloso, Marcia Paranho, Coelho, Camila de Morais, Viegas Junior, Claudio, Gontijo, Vanessa Silva, dos Santos, Marcelo Henrique, Meneghetti, Maria Cecília Zorél, Nader, Helena Bonciani, Tersariol, Ivarne Luis dos Santos, Juliano, Luiz, Juliano, Maria Aparecida, Judice, Wagner Alves de Souza
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2021
• Subjects: atherosclerosis; Biflavonoids - chemistry; Biflavonoids - pharmacology; Caco-2 Cells; flavonoids; forests; fungi; Furin - antagonists & inhibitors; Furin - metabolism; Garcinia brasiliensis; Humans; hyperglycemia; indigenous species; Inhibition mechanism; interleukin-8; Molecular Docking Simulation; Morelloflavone; neoplasms; osteoporosis; peptic ulcers; Proprotein Convertases - antagonists & inhibitors; Proprotein Convertases - metabolism; Proprotein Convertases subtilisin/kexin; pulp; secretion; Semisynthetic derivative biflanovoids; subtilisin; traditional medicine; Garcinia brasiliensis; Semisynthetic derivative biflanovoids; Caco-2 cells; Morelloflavone; Inhibition mechanism; Proprotein Convertases subtilisin/kexin

Garcinia brasiliensis is a species native to the Amazon forest. The white mucilaginous pulp is used in folk medicine as a wound healing agent and for peptic ulcer, urinary, and tumor disease treatments. The activity of the proprotein convertases (PCs) Subtilisin/Kex is associated with the developmen...