Semysinthetic biflavonoid Morelloflavone-7,4′,7″,3‴,4‴-penta-O-butanoyl is a more potent inhibitor of Proprotein Convertases Subtilisin/Kexin PC1/3 than Kex2 and Furin - de Souza, Aline Aparecida; de Andrade, Débora Martins; Siqueira, Fábio da Silva; Di Iorio, Juliana Fortes; Veloso, Marcia Paranho; Coelho, Camila de Morais; Viegas Junior, Claudio; Gontijo, Vanessa Silva; dos Santos, Marcelo Henrique; Meneghetti, Maria Cecília Zorél; Nader, Helena Bonciani; Tersariol, Ivarne Luis dos Santos; et al. (Biochimica et biophysica acta. General subjects, 2021)
Keywords: atherosclerosis; Biflavonoids - chemistry; Biflavonoids - pharmacology; Caco-2 Cells; flavonoids; forests; fungi; Furin - antagonists & inhibitors; Furin - metabolism; Garcinia brasiliensis; Humans; hyperglycemia; indigenous species; Inhibition mechanism; interleukin-8; Molecular Docking Simulation; Morelloflavone; neoplasms; osteoporosis; peptic ulcers; Proprotein Convertases - antagonists & inhibitors; Proprotein Convertases - metabolism; Proprotein Convertases subtilisin/kexin; pulp; secretion; Semisynthetic derivative biflanovoids; subtilisin; traditional medicine; Garcinia brasiliensis; Semisynthetic derivative biflanovoids; Caco-2 cells; Morelloflavone; Inhibition mechanism; Proprotein Convertases subtilisin/kexin