Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin

• Published in: Biochimica et biophysica acta Vol. 1840; no. 1; pp. 615 - 625
• Main Authors: Kim, Tae Hyung, Shin, Yu Jin, Won, A. Jin, Lee, Byung Mu, Choi, Wahn Soo, Jung, Jee H., Chung, Hae Young, Kim, Hyung Sik
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2014
• Subjects: ABC transporters; Animals; antineoplastic activity; Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis - drug effects; ATP Binding Cassette Transporter, Sub-Family B; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; Blotting, Western; Breast cancer; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Proliferation - drug effects; cytotoxicity; Doxorubicin; Doxorubicin - administration & dosage; Drug Resistance, Multiple - drug effects; Drug Resistance, Neoplasm - drug effects; Drug Synergism; Drug-resistant; Female; genes; Humans; in vivo studies; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins - genetics; Multidrug Resistance-Associated Proteins - metabolism; multiple drug resistance; neoplasm cells; Real-Time Polymerase Chain Reaction; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Stilbenes - administration & dosage; synergism; Tissue Distribution; Tumor Cells, Cultured; P-gp; Drug-resistant; DMSO; MRP; Breast cancer; Dox; Doxorubicin; DMEM; TUNEL; RSV; RT-PCR; Resveratrol; MCF-7/adr; MDR; ABC transporter; Multi-drug resistance; Terminal deoxynuclotidyl transferase dUTP nick end labeling; Dimethylsulfoxide; Dulbecco's Modified Eagle Medium; P-glycoprotein; Multi-drug resistance associated protein; Doxorubicin-resistant MCF-7; ATP-binding cassette transporter; Reverse transcription polymerase chain reaction

Multidrug resistance is a major problem in the treatment of breast cancer, and a number of studies have attempted to find an efficient strategy with which to overcome it. In this study, we investigate the synergistic anticancer effects of resveratrol (RSV) and doxorubicin (Dox) against human breast...