Preliminary MALDI-TOF-MS analysis of seminal plasma N-glycome of infertile men

• Published in: Carbohydrate research Vol. 435; pp. 19 - 25
• Main Authors: Kałuża, Anna, Jarząb, Anna, Gamian, Andrzej, Kratz, Ewa M., Zimmer, Mariusz, Ferens-Sieczkowska, Mirosława
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 29.11.2016
• Subjects: Adult; allografting; embryogenesis; females; Fetoembryonic defence; glycoproteins; Glycosylation; Humans; immune system; immunosuppression; Infertility, Male - etiology; Infertility, Male - metabolism; MALDI-TOF-TOF-MS/MS; Male; male fertility; Male infertility; mannose; matrix-assisted laser desorption-ionization mass spectrometry; men; Middle Aged; N-glycome; oligosaccharides; polysaccharides; Polysaccharides - analysis; Semen - chemistry; Seminal plasma; sialic acids; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; spermatozoa; tandem mass spectrometry; MALDI-TOF-TOF-MS/MS; N-glycome; Seminal plasma; Male infertility; Fetoembryonic defence

Glycosylation pattern within reproductive tract is now suggested to be involved in providing female immune tolerance for allograft sperm and developing embryo, but the information whether impaired glycosylation may influence male fertility potential is still limited. We have analyzed seminal plasma...