The KP.2-adapted COVID-19 vaccine improves neutralising activity against the XEC variant
The limitations of this study include the small cohort size, age group, examination of a single timepoint, and unknown effect of previous SARS-CoV-2 exposure or the cellular immune responses. The funders played no role in the design and conduct of the study; collection, management, analysis, and int...
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| Published in | The Lancet infectious diseases Vol. 25; no. 3; pp. e122 - e123 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.03.2025
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The limitations of this study include the small cohort size, age group, examination of a single timepoint, and unknown effect of previous SARS-CoV-2 exposure or the cellular immune responses. The funders played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. MSS served in an advisory role and received funds to conduct research from Ocugen. |
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| AbstractList | The limitations of this study include the small cohort size, age group, examination of a single timepoint, and unknown effect of previous SARS-CoV-2 exposure or the cellular immune responses. The funders played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. MSS served in an advisory role and received funds to conduct research from Ocugen. |
| Author | Harcourt, Jennifer Douek, Daniel C Godbole, Sucheta Paden, Clinton Moreno, Alberto Vander Velden, Jake Rouphael, Nadine Bechnak, Kareem Bowen, Nicole Dib, Serena M Cook, Peter Jain, Shilpi Kim, Sungjin Radi, Christelle Tamin, Azaibi Ellis, Madison L Kalash, Suha Suthar, Mehul S Manning, Kelly E Laboune, Farida Henry, Amy R Pinsky, Benjamin A Paredes, Isabel Hicks, Heather Sahoo, Malaya K Gardner, Meredith |
| Author_xml | – sequence: 1 givenname: Mehul S surname: Suthar fullname: Suthar, Mehul S email: msuthar@emory.edu organization: Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA – sequence: 2 givenname: Kelly E surname: Manning fullname: Manning, Kelly E organization: Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA – sequence: 3 givenname: Madison L surname: Ellis fullname: Ellis, Madison L organization: Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA – sequence: 4 givenname: Shilpi surname: Jain fullname: Jain, Shilpi organization: Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA – sequence: 5 givenname: Kareem surname: Bechnak fullname: Bechnak, Kareem organization: Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA, USA – sequence: 6 givenname: Jake surname: Vander Velden fullname: Vander Velden, Jake organization: Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA – sequence: 7 givenname: Farida surname: Laboune fullname: Laboune, Farida organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA – sequence: 8 givenname: Amy R surname: Henry fullname: Henry, Amy R organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA – sequence: 9 givenname: Sucheta surname: Godbole fullname: Godbole, Sucheta organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA – sequence: 10 givenname: Sungjin surname: Kim fullname: Kim, Sungjin organization: Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30329, USA – sequence: 11 givenname: Malaya K surname: Sahoo fullname: Sahoo, Malaya K organization: Stanford University School of Medicine, Stanford, CA, USA – sequence: 12 givenname: Isabel surname: Paredes fullname: Paredes, Isabel organization: Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA, USA – sequence: 13 givenname: Serena M surname: Dib fullname: Dib, Serena M organization: Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA, USA – sequence: 14 givenname: Suha surname: Kalash fullname: Kalash, Suha organization: Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA, USA – sequence: 15 givenname: Christelle surname: Radi fullname: Radi, Christelle organization: Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA, USA – sequence: 16 givenname: Heather surname: Hicks fullname: Hicks, Heather organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 17 givenname: Azaibi surname: Tamin fullname: Tamin, Azaibi organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 18 givenname: Meredith surname: Gardner fullname: Gardner, Meredith organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 19 givenname: Nicole surname: Bowen fullname: Bowen, Nicole organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 20 givenname: Peter surname: Cook fullname: Cook, Peter organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 21 givenname: Clinton surname: Paden fullname: Paden, Clinton organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 22 givenname: Jennifer surname: Harcourt fullname: Harcourt, Jennifer organization: Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA – sequence: 23 givenname: Benjamin A surname: Pinsky fullname: Pinsky, Benjamin A organization: Stanford University School of Medicine, Stanford, CA, USA – sequence: 24 givenname: Daniel C surname: Douek fullname: Douek, Daniel C organization: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA – sequence: 25 givenname: Nadine surname: Rouphael fullname: Rouphael, Nadine organization: Hope Clinic of Emory Vaccine Center, Emory University, Decatur, GA, USA – sequence: 26 givenname: Alberto surname: Moreno fullname: Moreno, Alberto email: camoren@emory.edu organization: Emory Vaccine Center, Emory University, Atlanta, GA, USA |
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| References_xml | – volume: 73 start-page: 819 year: 2024 end-page: 824 ident: bib3 article-title: Use of COVID-19 vaccines for persons aged ≥6 months: recommendations of the advisory committee on immunization practices - United States, 2024–2025 publication-title: MMWR Morb Mortal Wkly Rep – volume: 43 year: 2024 ident: bib2 article-title: Neutralization escape, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 SLip, FLiRT, and KP.2 variants publication-title: Cell Rep – volume: 27 year: 2024 ident: bib1 article-title: Rapid spread of the SARS-CoV-2 JN.1 lineage is associated with increased neutralization evasion publication-title: iScience – volume: 3 year: 2022 ident: bib4 article-title: mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant publication-title: Cell Rep Med – volume: 25 start-page: e6 year: 2024 end-page: e7 ident: bib5 article-title: Enhanced immune evasion of SARS-CoV-2 variants KP.3.1.1 and XEC through N-terminal domain mutations publication-title: Lancet Infect Dis – volume: 25 start-page: e6 year: 2024 ident: 10.1016/S1473-3099(25)00007-6_bib5 article-title: Enhanced immune evasion of SARS-CoV-2 variants KP.3.1.1 and XEC through N-terminal domain mutations publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(24)00738-2 – volume: 3 year: 2022 ident: 10.1016/S1473-3099(25)00007-6_bib4 article-title: mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant publication-title: Cell Rep Med – volume: 43 year: 2024 ident: 10.1016/S1473-3099(25)00007-6_bib2 article-title: Neutralization escape, infectivity, and membrane fusion of JN.1-derived SARS-CoV-2 SLip, FLiRT, and KP.2 variants publication-title: Cell Rep doi: 10.1016/j.celrep.2024.114520 – volume: 27 year: 2024 ident: 10.1016/S1473-3099(25)00007-6_bib1 article-title: Rapid spread of the SARS-CoV-2 JN.1 lineage is associated with increased neutralization evasion publication-title: iScience – volume: 73 start-page: 819 year: 2024 ident: 10.1016/S1473-3099(25)00007-6_bib3 article-title: Use of COVID-19 vaccines for persons aged ≥6 months: recommendations of the advisory committee on immunization practices - United States, 2024–2025 publication-title: MMWR Morb Mortal Wkly Rep doi: 10.15585/mmwr.mm7337e2 |
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| Title | The KP.2-adapted COVID-19 vaccine improves neutralising activity against the XEC variant |
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