Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety

• Published in: Phytomedicine (Stuttgart) Vol. 58; p. 152871
• Main Authors: Jia, Qiangqiang, Zhu, Ruyuan, Tian, Yimiao, Chen, Beibei, Li, Rui, Li, Lin, Wang, Lili, Che, Yiwen, Zhao, Dandan, Mo, Fangfang, Gao, Sihua, Zhang, Dongwei
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.05.2019
• Subjects: animals; apoptosis; blood circulation; blood stasis; chemical constituents of plants; China; clinical trials; Diabetes; diterpenoids; enzymes; glycemic effect; herbs; homeostasis; inflammation; ingredients; medicinal properties; obesity; Oriental traditional medicine; peroxisome proliferator-activated receptors; Pharmacology; Phytochemistry; Safety; Salvia miltiorrhiza; signal transduction; subacute toxicity; toxicity testing; vascular endothelial growth factors; China; T1DM; OASF; eNOS; TORC2; JNK; OLETF; HFD; LVEF; DM; MDA; AP-1; I/R; TNF; CTGF; BSA; NF-κB; PI3K; PPAR; oxLDL; STZ; iNOS; IL; PEPCK; i.p; CaMKKβ; BH2; ADEs; BH4; CVD; i.v; G6Pase; Phytochemistry; GSH-GPx; NOX; nNOS; ROS; AMPK; TXNIP; HUVECs; TCM; CRP; NO; T2DM; MCP-1; TTE; vWF; IRS-1; LPL; HO-1; PARP; LKB1; SMDS; BCL-2; SD; TSP-1; Sirt 3; BW; Nrf2; NLRP3; ADRs; SM; Safety; hIAPP; GSH; αP2; 8-OHdG; ACC; CD; HSP90; NQO1; RAGEs; VEGF; STAT3; HSHF; IKK; SOD; Pharmacology; AGEs; PGC-1α; PP2-A; UCP-2; Akt; ECM; GSK3β; SMHE; Salvia miltiorrhiza; ChREBP; PTP1B; Keap1; FAS; TGF-β1; Diabetes; CHD

Salvia miltiorrhiza (SM), one of the frequently used herbs in traditional Chinese medicine (TCM), has now attracted rising interests for a possible alternative in the management of diabetes. This review is aimed to providing a comprehensive perspective of SM in phytochemical constituents, pharmacolo...