An Adaptive and Robust Test for Microbial Community Analysis

• Published in: Frontiers in genetics Vol. 13; p. 846258
• Main Authors: Chen, Qingyu, Lin, Shili, Song, Chi
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 19.05.2022
• Subjects: adaptive combination of p-values; association test; community-level test; Genetics; human microbiome; OTU-level test; community-level test; adaptive combination of p-values; association test; human microbiome; OTU-level test

In microbiome studies, researchers measure the abundance of each operational taxon unit (OTU) and are often interested in testing the association between the microbiota and the clinical outcome while conditional on certain covariates. Two types of approaches exists for this testing purpose: the OTU-...