Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 9; pp. 1417 - 1428
• Main Authors: Botelho, R.M., Tenorio, L.P.G., Silva, A.L.M., Tanabe, E.L.L., Pires, K.S.N., Gonçalves, C.M., Santos, J.C., Marques, A.L.X., Allard, M.J., Bergeron, J.D., Sebire, G., Silva, E.C.O., Souza, S.T., Fonseca, E.J.S., Borbely, A.U., Borbely, K.S.C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2019
• Subjects: Animals; Atomic force microscopy; bacteria; Biological Transport; Biomechanical Phenomena; biomechanics; Cell Death; Cell Line; Cell Nucleus - metabolism; Cell Survival; cell viability; Chlorocebus aethiops; Chorioamnionitis; Cytokines - metabolism; cytoskeleton; death; diet; Female; fluorescent antibody technique; functional properties; Group B Streptococcus; Humans; inflammation; interferon-gamma; interleukin-1beta; interleukin-2; interleukin-4; NF-kappa B - metabolism; nitrites; Nitrites - metabolism; olive oil; Placenta; Pregnancy; pregnant women; secretion; Streptococcus agalactiae; Streptococcus agalactiae - pathogenicity; Th1 Cells - metabolism; Triterpenes - pharmacology; triterpenoids; Trophoblast; Trophoblasts - drug effects; Trophoblasts - metabolism; Trophoblasts - microbiology; Uvaol; Vero Cells; Atomic force microscopy; Uvaol; Trophoblast; Chorioamnionitis; Placenta; Group B Streptococcus

Group B streptococcus (GBS) is the main bacteria that infects pregnant women and can cause abortion and chorioamnionitis. The impact of GBS effects on human trophoblast cells remains largely elusive, and actions toward anti-inflammatory strategies in pregnancy are needed. A potent anti-inflammatory...