The relationship between gray/white matter contrast and cognitive performance in first-episode schizophrenia
Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness...
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| Published in | Cerebral cortex (New York, N.Y. 1991) Vol. 34; no. 2 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Oxford University Press
31.01.2024
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| ISSN | 1047-3211 1460-2199 1460-2199 |
| DOI | 10.1093/cercor/bhae009 |
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| Abstract | Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages. |
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| AbstractList | Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages. Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages.Previous postmortem brain studies have revealed disturbed myelination in the intracortical regions in patients with schizophrenia, possibly reflecting anomalous brain maturational processes. However, it currently remains unclear whether this anomalous myelination is already present in early illness stages and/or progresses during the course of the illness. In this magnetic resonance imaging study, we examined gray/white matter contrast (GWC) as a potential marker of intracortical myelination in 63 first-episode schizophrenia (FESz) patients and 77 healthy controls (HC). Furthermore, we investigated the relationships between GWC findings and clinical/cognitive variables in FESz patients. GWC in the bilateral temporal, parietal, occipital, and insular regions was significantly higher in FESz patients than in HC, which was partly associated with the durations of illness and medication, the onset age, and lower executive and verbal learning performances. Because higher GWC implicates lower myelin in the deeper layers of the cortex, these results suggest that schizophrenia patients have less intracortical myelin at the time of their first psychotic episode, which underlies lower cognitive performance in early illness stages. |
| Author | Kido, Mikio Suzuki, Michio Takayanagi, Yoichiro Noguchi, Kyo Sasabayashi, Daiki Kobayashi, Haruko Furuichi, Atsushi Takahashi, Tsutomu |
| Author_xml | – sequence: 1 givenname: Haruko surname: Kobayashi fullname: Kobayashi, Haruko email: kbhr310@med.u-toyama.ac.jp – sequence: 2 givenname: Daiki orcidid: 0000-0001-8512-7438 surname: Sasabayashi fullname: Sasabayashi, Daiki email: ds179@med.u-toyama.ac.jp – sequence: 3 givenname: Tsutomu surname: Takahashi fullname: Takahashi, Tsutomu email: tsutomu@med.u-toyama.ac.jp – sequence: 4 givenname: Atsushi surname: Furuichi fullname: Furuichi, Atsushi email: ichi1031@med.u-toyama.ac.jp – sequence: 5 givenname: Mikio surname: Kido fullname: Kido, Mikio email: mikiokido@gmail.com – sequence: 6 givenname: Yoichiro surname: Takayanagi fullname: Takayanagi, Yoichiro email: ytakayan1@outlook.jp – sequence: 7 givenname: Kyo surname: Noguchi fullname: Noguchi, Kyo email: kyo@med.u-toyama.ac.jp – sequence: 8 givenname: Michio surname: Suzuki fullname: Suzuki, Michio email: suzukim@med.u-toyama.ac.jp |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38265871$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1001_jamanetworkopen_2024_51786 crossref_primary_10_1016_j_biopsych_2024_10_008 |
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| Keywords | executive dysfunction magnetic resonance imaging schizophrenia verbal learning deficits intracortical myelin |
| Language | English |
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