Role of potassium channels in chlorogenic acid-induced apoptotic volume decrease and cell cycle arrest in Candida albicans

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 3; pp. 585 - 592
• Main Authors: Yun, JiEun, Lee, Dong Gun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017
• Subjects: Antifungal Agents - pharmacology; antifungal properties; apoptosis; Apoptosis - drug effects; Apoptotic volume decrease; Biomarkers - metabolism; calcium; Calcium - metabolism; Candida albicans; Candida albicans - drug effects; Candida albicans - metabolism; caspases; Cell cycle arrest; cell cycle checkpoints; Cell Cycle Checkpoints - drug effects; chloride channels; Chloride Channels - antagonists & inhibitors; Chlorogenic acid; Chlorogenic Acid - pharmacology; Cytosol - drug effects; Cytosol - metabolism; DNA fragmentation; DNA Fragmentation - drug effects; flow cytometry; homeostasis; human nutrition; potassium; Potassium channel; Potassium Channel Blockers - pharmacology; potassium channels; Potassium Channels - metabolism; potassium chloride; Reactive Oxygen Species - metabolism; staining; TEA; CRA; DIDS; Apoptotic volume decrease; Cell cycle arrest; Chlorogenic acid; Potassium channel; AVD

Chlorogenic acid (CRA) is an abundant phenolic compound in the human diet. CRA has a potent antifungal effect, inducing cell death in Candida albicans. However, there are no further studies to investigate the antifungal mechanism of CRA, associated with ion channels. To evaluate the inhibitory effec...