Deregulation of Bmi-1 is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma

• Published in: Biochimica et biophysica acta Vol. 1840; no. 12; pp. 3285 - 3291
• Main Authors: Chang, Boyang, Li, Su, He, Qianting, Liu, Zhonghua, Zhao, Luodan, Zhao, Tingting, Wang, Anxun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2014
• Subjects: Bmi-1; carcinogenesis; carcinoma; Metastasis; prognosis; Salivary adenoid cystic carcinoma; stem cells; vimentin; Salivary adenoid cystic carcinoma; Bmi-1; Metastasis

Bmi-1 had been found to involve in self renewal of stem cells and tumorigenesis in various malignancies. In this study, we investigated the role of Bmi-1 in the development of salivary adenoid cystic carcinoma (SACC). At first, we confirmed that the deregulation of Bmi-1 was a frequent event in SACC...