ESM-1 silencing decreased cell survival, migration, and invasion and modulated cell cycle progression in hepatocellular carcinoma

• Published in: Amino acids Vol. 40; no. 3; pp. 1003 - 1013
• Main Authors: Kang, Yun Hee, Ji, Na Young, Lee, Chung Il, Lee, Hee Gu, Kim, Jae Wha, Yeom, Young IL, Kim, Dae Ghon, Yoon, Seung Kew, Kim, Jong Wan, Park, Pil Je, Song, Eun Young
• Format: Journal Article
• Language: English
• Published: Vienna Vienna : Springer Vienna 01.03.2011; Springer Vienna; Springer Nature B.V
• Subjects: Analytical Chemistry; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - physiopathology; Cell Cycle; Cell Line, Tumor; Cell migration; Cell Movement; Cell Survival; Diagnostic marker; ESM-1; Gene Silencing; hepatoma; Humans; Life Sciences; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - physiopathology; Neoplasm Invasiveness; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neurobiology; Original Article; Proteoglycans - genetics; Proteoglycans - metabolism; Proteomics; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; ESM-1; Diagnostic marker; Hepatocellular carcinoma; Cell migration; Cell cycle

Endothelial cell-specific molecule-1 (ESM-1) is a secretory proteoglycan comprising a mature polypeptide of 165 amino acids and a single dermatan sulfate. The aim of this study was to evaluate endothelial cell-specific molecule-1 (ESM-1) as a hepatocellular carcinoma (HCC) marker and to analyze the...