Receptor-based targeting of engineered nanocarrier against solid tumors: Recent progress and challenges ahead

Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity. Scope of review The applicabilit...

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Published inBiochimica et biophysica acta. General subjects Vol. 1865; no. 2; p. 129777
Main Authors Akhter, Md. Habban, Beg, Sarwar, Tarique, Mohammed, Malik, Arshi, Afaq, Sarah, Choudhry, Hani, Hosawi, Salman
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.02.2021
Subjects
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Cancer
cancer therapy
Drug Carriers - chemistry
Drug Carriers - metabolism
Drug delivery
Drug Delivery Systems - methods
drugs
ErbB Receptors - metabolism
Humans
nanocarriers
nanomedicine
Nanomedicine - methods
Nanomedicines
neoplasms
Neoplasms - drug therapy
Neoplasms - metabolism
permeability
Receptor targeting
Theranostics
Tumor metastasis
Tumor Microenvironment - drug effects
Receptor targeting
Drug delivery
Theranostics
Nanomedicines
Cancer
Tumor metastasis
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Abstract Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity. Scope of review The applicability of enhanced permeability and retention (EPR) effect for the delivery of nanomedicines in cancer therapy has gained limited success due to poor accessibility of the drugs to the target cells where non-specific payload delivery to the off target region lack substantial reward over the conventional therapeutic systems. Major conclusions In spite of the fact, nanomedicines fabricated from the biocompatible nanocarriers have reduced targeting potential for meaningful clinical benefits. However, over expression of receptors on the tumor cells provides opportunity to design functional nanomedicine to bind substantially and deliver therapeutics to the cells or tissues of interest by alleviating the bio-toxicity and unwanted effects. This critique will give insight into the over expressed receptor in various tumor and targeting potential of functional nanomedicine as new therapeutic avenues for effective treatment. General significance This review shortly shed light on EPR-based drug targeting using nanomedicinal strategies, their limitation, and advances in therapeutic targeting to the tumor cells. •Engineering nanocarriers have gained attention in cancer due to receptor targeting.•EPR based nanomedicines exhibit limited success due to poor drug retention in target cells.•TME is an important key domain for designing any NCs for effective drug targeting.•The active targeting is meant for improving targeting of NCs for better therapeutic efficacy.
AbstractList BackgroundIn past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity.Scope of reviewThe applicability of enhanced permeability and retention (EPR) effect for the delivery of nanomedicines in cancer therapy has gained limited success due to poor accessibility of the drugs to the target cells where non-specific payload delivery to the off target region lack substantial reward over the conventional therapeutic systems.Major conclusionsIn spite of the fact, nanomedicines fabricated from the biocompatible nanocarriers have reduced targeting potential for meaningful clinical benefits. However, over expression of receptors on the tumor cells provides opportunity to design functional nanomedicine to bind substantially and deliver therapeutics to the cells or tissues of interest by alleviating the bio-toxicity and unwanted effects. This critique will give insight into the over expressed receptor in various tumor and targeting potential of functional nanomedicine as new therapeutic avenues for effective treatment.General significanceThis review shortly shed light on EPR-based drug targeting using nanomedicinal strategies, their limitation, and advances in therapeutic targeting to the tumor cells.
Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity. Scope of review The applicability of enhanced permeability and retention (EPR) effect for the delivery of nanomedicines in cancer therapy has gained limited success due to poor accessibility of the drugs to the target cells where non-specific payload delivery to the off target region lack substantial reward over the conventional therapeutic systems. Major conclusions In spite of the fact, nanomedicines fabricated from the biocompatible nanocarriers have reduced targeting potential for meaningful clinical benefits. However, over expression of receptors on the tumor cells provides opportunity to design functional nanomedicine to bind substantially and deliver therapeutics to the cells or tissues of interest by alleviating the bio-toxicity and unwanted effects. This critique will give insight into the over expressed receptor in various tumor and targeting potential of functional nanomedicine as new therapeutic avenues for effective treatment. General significance This review shortly shed light on EPR-based drug targeting using nanomedicinal strategies, their limitation, and advances in therapeutic targeting to the tumor cells. •Engineering nanocarriers have gained attention in cancer due to receptor targeting.•EPR based nanomedicines exhibit limited success due to poor drug retention in target cells.•TME is an important key domain for designing any NCs for effective drug targeting.•The active targeting is meant for improving targeting of NCs for better therapeutic efficacy.
Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity. Scope of review The applicability of enhanced permeability and retention (EPR) effect for the delivery of nanomedicines in cancer therapy has gained limited success due to poor accessibility of the drugs to the target cells where non-specific payload delivery to the off target region lack substantial reward over the conventional therapeutic systems. Major conclusions In spite of the fact, nanomedicines fabricated from the biocompatible nanocarriers have reduced targeting potential for meaningful clinical benefits. However, over expression of receptors on the tumor cells provides opportunity to design functional nanomedicine to bind substantially and deliver therapeutics to the cells or tissues of interest by alleviating the bio-toxicity and unwanted effects. This critique will give insight into the over expressed receptor in various tumor and targeting potential of functional nanomedicine as new therapeutic avenues for effective treatment. General significance This review shortly shed light on EPR-based drug targeting using nanomedicinal strategies, their limitation, and advances in therapeutic targeting to the tumor cells.
Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity. Scope of review The applicability of enhanced permeability and retention (EPR) effect for the delivery of nanomedicines in cancer therapy has gained limited success due to poor accessibility of the drugs to the target cells where non-specific payload delivery to the off target region lack substantial reward over the conventional therapeutic systems. Major conclusions In spite of the fact, nanomedicines fabricated from the biocompatible nanocarriers have reduced targeting potential for meaningful clinical benefits. However, over expression of receptors on the tumor cells provides opportunity to design functional nanomedicine to bind substantially and deliver therapeutics to the cells or tissues of interest by alleviating the bio-toxicity and unwanted effects. This critique will give insight into the over expressed receptor in various tumor and targeting potential of functional nanomedicine as new therapeutic avenues for effective treatment. General significance This review shortly shed light on EPR-based drug targeting using nanomedicinal strategies, their limitation, and advances in therapeutic targeting to the tumor cells.Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of drug molecules on the diseased cells thereby preventing unwanted uptake into healthy cells to cause toxicity. Scope of review The applicability of enhanced permeability and retention (EPR) effect for the delivery of nanomedicines in cancer therapy has gained limited success due to poor accessibility of the drugs to the target cells where non-specific payload delivery to the off target region lack substantial reward over the conventional therapeutic systems. Major conclusions In spite of the fact, nanomedicines fabricated from the biocompatible nanocarriers have reduced targeting potential for meaningful clinical benefits. However, over expression of receptors on the tumor cells provides opportunity to design functional nanomedicine to bind substantially and deliver therapeutics to the cells or tissues of interest by alleviating the bio-toxicity and unwanted effects. This critique will give insight into the over expressed receptor in various tumor and targeting potential of functional nanomedicine as new therapeutic avenues for effective treatment. General significance This review shortly shed light on EPR-based drug targeting using nanomedicinal strategies, their limitation, and advances in therapeutic targeting to the tumor cells.
ArticleNumber 129777
Author Akhter, Md. Habban
Tarique, Mohammed
Afaq, Sarah
Hosawi, Salman
Choudhry, Hani
Malik, Arshi
Beg, Sarwar
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  fullname: Tarique, Mohammed
  organization: Center for Interdisciplinary Research in Basic Science, Jamia Millia Islamia, New Delhi, India
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  surname: Malik
  fullname: Malik, Arshi
  organization: Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia
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  surname: Afaq
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  organization: Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Saudi Arabia
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  organization: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
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  givenname: Salman
  surname: Hosawi
  fullname: Hosawi, Salman
  organization: Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
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Keywords Receptor targeting
Drug delivery
Theranostics
Nanomedicines
Cancer
Tumor metastasis
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Snippet Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of...
Background In past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of...
BackgroundIn past few decades, the research on engineered nanocarriers (NCs) has gained significant attention in cancer therapy due to selective delivery of...
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SubjectTerms Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Cancer
cancer therapy
Drug Carriers - chemistry
Drug Carriers - metabolism
Drug delivery
Drug Delivery Systems - methods
drugs
ErbB Receptors - metabolism
Humans
nanocarriers
nanomedicine
Nanomedicine - methods
Nanomedicines
neoplasms
Neoplasms - drug therapy
Neoplasms - metabolism
permeability
Receptor targeting
Theranostics
Tumor metastasis
Tumor Microenvironment - drug effects
Title Receptor-based targeting of engineered nanocarrier against solid tumors: Recent progress and challenges ahead
URI https://dx.doi.org/10.1016/j.bbagen.2020.129777
https://www.ncbi.nlm.nih.gov/pubmed/33130062
https://www.proquest.com/docview/2456861422
https://www.proquest.com/docview/2551921161
Volume 1865
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