Diurnal regulation of sphingolipids in blood

• Published in: Biochimica et biophysica acta. Molecular and cell biology of lipids Vol. 1864; no. 3; pp. 304 - 311
• Main Authors: Brunkhorst, Robert, Pfeilschifter, Waltraud, Rajkovic, Natasa, Pfeffer, Martina, Fischer, Claudia, Korf, Horst-Werner, Christoffersen, Christina, Trautmann, Sandra, Thomas, Dominique, Pfeilschifter, Josef, Koch, Alexander
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019
• Subjects: Blood; blood platelets; circadian rhythm; humans; knockout mutants; mass spectrometry; Melatonin; metabolism; mice; pathophysiology; photophase; proteins; Sphingolipids; sphingosine; Sphingosine 1-phosphate; Melatonin; Sphingolipids; Blood; Sphingosine 1-phosphate

Key homeostatic functions are regulated in a diurnal manner and a miss-alignment of such rhythms is believed to contribute to the pathophysiology of several diseases. Signaling sphingolipids (SLs) in plasma such as sphingosine 1-phosphate control lymphocytic trafficking, vascular reactivity and plat...