High levels of cAMP inhibit Pseudomonas aeruginosa biofilm formation through reduction of the c-di-GMP content

• Published in: Microbiology (Society for General Microbiology) Vol. 165; no. 3; pp. 324 - 333
• Main Authors: Almblad, Henrik, Rybtke, Morten, Hendiani, Saghar, Andersen, Jens Bo, Givskov, Michael, Tolker-Nielsen, Tim
• Format: Journal Article
• Language: English
• Published: England 01.03.2019
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biofilms - growth & development; Cyclic AMP - metabolism; Cyclic AMP Receptor Protein - genetics; Cyclic AMP Receptor Protein - metabolism; Cyclic GMP - analogs & derivatives; Cyclic GMP - metabolism; Extracellular Polymeric Substance Matrix - metabolism; Mutation; Phosphoric Diester Hydrolases - genetics; Phosphoric Diester Hydrolases - metabolism; Pseudomonas aeruginosa - genetics; Pseudomonas aeruginosa - growth & development; Pseudomonas aeruginosa - metabolism; Pseudomonas aeruginosa - physiology; Pseudomonas aeruginosa; biofilm formation; c-di-GMP; cAMP; virulence factors

The human pathogen Pseudomonas aeruginosa can cause both acute infections and chronic biofilm-based infections. Expression of acute virulence factors is positively regulated by cAMP, whereas biofilm formation is positively regulated by c-di-GMP. We provide evidence that increased levels of cAMP, cau...