The receptor tyrosine kinase ERBB4 is expressed in skin keratinocytes and influences epidermal proliferation

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 4; pp. 958 - 966
• Main Authors: Hoesl, Christine, Röhrl, Jennifer M., Schneider, Marlon R., Dahlhoff, Maik
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2018
• Subjects: A431; Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; EGFR; epidermal growth factor; Epidermal Growth Factor - pharmacology; epidermal growth factor receptors; Epidermis - cytology; Epidermis - drug effects; Epidermis - metabolism; ERBB4; fluorescent antibody technique; Gene Expression - drug effects; HaCaT; homeostasis; human cell lines; Humans; keratinocytes; Keratinocytes - metabolism; Knockout; ligands; messenger RNA; mice; Mice, Knockout; Mouse model; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Receptor, ErbB-4 - genetics; Receptor, ErbB-4 - metabolism; Skin - cytology; Skin - metabolism; Western blotting; Mouse model; ERBB4; HaCaT; EGFR; Knockout; A431

The epidermal growth factor receptor (EGFR) and associated receptors ERBB2 and ERBB3 are important for skin development and homeostasis. To date, ERBB4 could not be unambiguously identified in the epidermis. The aim of this study was to analyze the ERBB-receptor family with a special focus on ERBB4...