NABi, a novel β-sheet breaker, inhibits Aβ aggregation and neuronal toxicity: Therapeutic implications for Alzheimer's disease

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 1; pp. 71 - 80
• Main Authors: Jang, Ja-Young, Rhim, Hyangshuk, Kang, Seongman
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2018
• Subjects: Alzheimer disease; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; amyloid; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - metabolism; Animals; cell death; Cell Line, Tumor; cytotoxicity; Humans; Mice; neurodegenerative diseases; neurons; Neurons - metabolism; Neurons - pathology; pathogenesis; Protein Aggregation, Pathological - drug therapy; Protein Aggregation, Pathological - metabolism; Protein Aggregation, Pathological - pathology; Protein Structure, Secondary; superoxide dismutase; Superoxide Dismutase - antagonists & inhibitors; Superoxide Dismutase - metabolism

Amyloid beta (Aβ) aggregates are an important therapeutic target for Alzheimer's disease (AD), a fatal neurodegenerative disease. To date, AD still remains a big challenge due to no effective treatments. Based on the property that Aβ aggregates have the cross-β-structure, a common structural fe...