Retention reproducibility of thiazide diuretics and related drugs in reversed-phase high-performance liquid chromatography

• Published in: Journal of chromatography Vol. 384; p. 259
• Main Authors: Smith, R M, Murilla, G A, Hurdley, T G, Gill, R, Moffat, A C
• Format: Journal Article
• Language: English
• Published: Netherlands 02.01.1987
• Subjects: Acetates; Acetonitriles - analysis; Benzothiadiazines; Chromatography, High Pressure Liquid; Diuretics - analysis; Hydrogen-Ion Concentration; Sodium Chloride Symporter Inhibitors - analysis; Solvents; Temperature

A method has been developed for the separation of thiazide diuretics and a number of related drugs by high-performance liquid chromatography on an ODS-Hypersil column with acetonitrile-1% aqueous acetic acid as the eluent. The effects caused by changes in the separation conditions on the reproducibi...