Self-calcifying lipid nanocarrier for bone tissue engineering

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 2; p. 130047
• Main Authors: Chaiin, Poowadon, Yostaworakul, Jakarwan, Rungnim, Chompoonut, Khemthong, Pongtanawat, Yata, Teerapong, Boonrungsiman, Suwimon
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2022
• Subjects: active ingredients; body fluids; Bone and Bones - metabolism; bones; Calcification, Physiologic - drug effects; calcium; Calcium phosphate; calcium phosphates; Calcium Phosphates - chemistry; cholecalciferol; Cholecalciferol - chemistry; Collagen; Density functional theory; Drug Carriers - chemistry; emulsifying; Emulsions - chemistry; Humans; lipids; Lipids - chemistry; lipophilicity; nanocarriers; Nanoemulsion; nanoemulsions; Nanoparticles - chemistry; polysorbates; Self-calcification; Tissue Engineering - methods; EE; DI; Nanoemulsion; Calcium phosphate; MV; FT-IR; ACP; LNP; CaP; DFT; Ca2; Collagen; SBF; EDX; Density functional theory; HA; SEM; PO43; Self-calcification; TEM; MCT

A nanoemulsion with specific surface properties (such as charge and functional groups) can initiate the deposition of calcium phosphate (CaP) on its surface, leading to formation of CaP nanoparticles with a lipid core. The lipid core can carry lipophilic compounds based on the function of the nanoem...