Post-translational regulation and modifications of flavivirus structural proteins

Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally circulate between arthropod vectors and susceptible vertebrate hosts, producing significant human and veterinary disease burdens. Intensive research efforts have broadened our scientific understanding of the repli...

Full description

Saved in:
Bibliographic Details
Published inJournal of general virology Vol. 96; no. Pt 7; pp. 1551 - 1569
Main Authors Roby, Justin A, Setoh, Yin Xiang, Hall, Roy A, Khromykh, Alexander A
Format Journal Article
LanguageEnglish
Published England 01.07.2015
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally circulate between arthropod vectors and susceptible vertebrate hosts, producing significant human and veterinary disease burdens. Intensive research efforts have broadened our scientific understanding of the replication cycles of these viruses and have revealed several elegant and tightly co-ordinated post-translational modifications that regulate the activity of viral proteins. The three structural proteins in particular - capsid (C), pre-membrane (prM) and envelope (E) - are subjected to strict regulatory modifications as they progress from translation through virus particle assembly and egress. The timing of proteolytic cleavage events at the C-prM junction directly influences the degree of genomic RNA packaging into nascent virions. Proteolytic maturation of prM by host furin during Golgi transit facilitates rearrangement of the E proteins at the virion surface, exposing the fusion loop and thus increasing particle infectivity. Specific interactions between the prM and E proteins are also important for particle assembly, as prM acts as a chaperone, facilitating correct conformational folding of E. It is only once prM/E heterodimers form that these proteins can be secreted efficiently. The addition of branched glycans to the prM and E proteins during virion transit also plays a key role in modulating the rate of secretion, pH sensitivity and infectivity of flavivirus particles. The insights gained from research into post-translational regulation of structural proteins are beginning to be applied in the rational design of improved flavivirus vaccine candidates and make attractive targets for the development of novel therapeutics.
AbstractList Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally circulate between arthropod vectors and susceptible vertebrate hosts, producing significant human and veterinary disease burdens. Intensive research efforts have broadened our scientific understanding of the replication cycles of these viruses and have revealed several elegant and tightly co-ordinated post-translational modifications that regulate the activity of viral proteins. The three structural proteins in particular - capsid (C), pre-membrane (prM) and envelope (E) - are subjected to strict regulatory modifications as they progress from translation through virus particle assembly and egress. The timing of proteolytic cleavage events at the C-prM junction directly influences the degree of genomic RNA packaging into nascent virions. Proteolytic maturation of prM by host furin during Golgi transit facilitates rearrangement of the E proteins at the virion surface, exposing the fusion loop and thus increasing particle infectivity. Specific interactions between the prM and E proteins are also important for particle assembly, as prM acts as a chaperone, facilitating correct conformational folding of E. It is only once prM/E heterodimers form that these proteins can be secreted efficiently. The addition of branched glycans to the prM and E proteins during virion transit also plays a key role in modulating the rate of secretion, pH sensitivity and infectivity of flavivirus particles. The insights gained from research into post-translational regulation of structural proteins are beginning to be applied in the rational design of improved flavivirus vaccine candidates and make attractive targets for the development of novel therapeutics.
Author Roby, Justin A
Hall, Roy A
Setoh, Yin Xiang
Khromykh, Alexander A
Author_xml – sequence: 1
  givenname: Justin A
  surname: Roby
  fullname: Roby, Justin A
  organization: 1Australian Infectious Diseases Research Centre, The University of Queensland, Australia 2School of Chemistry and Molecular Biosciences, The University of Queensland, Australia
– sequence: 2
  givenname: Yin Xiang
  surname: Setoh
  fullname: Setoh, Yin Xiang
  organization: 1Australian Infectious Diseases Research Centre, The University of Queensland, Australia 2School of Chemistry and Molecular Biosciences, The University of Queensland, Australia
– sequence: 3
  givenname: Roy A
  surname: Hall
  fullname: Hall, Roy A
  organization: 1Australian Infectious Diseases Research Centre, The University of Queensland, Australia 2School of Chemistry and Molecular Biosciences, The University of Queensland, Australia
– sequence: 4
  givenname: Alexander A
  surname: Khromykh
  fullname: Khromykh, Alexander A
  organization: 1Australian Infectious Diseases Research Centre, The University of Queensland, Australia 2School of Chemistry and Molecular Biosciences, The University of Queensland, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25711963$$D View this record in MEDLINE/PubMed
BookMark eNo9UMtKxDAUDTLiPHTnWrp0YWseTTtZyuALBlTQdchTIm0zJumAf2-0o3dzX-eewz1LMBv8YAA4R7BCkLHrvQsVrGAO1h6BBaobWuK8mIEFhBiXiKB2DpYxfkCI6pq2J2COaYsQa8gCvDz7mMoUxBA7kZwfRFcE8z5OTSEGXfReO-vU7yAW3ha2E3uXZcdYxBRGlcaQr3bBJ-OGeAqOreiiOTvkFXi7u33dPJTbp_vHzc22VITRVGJsJGooVpa0tEZYr62uscHIyjoXhFoqrWasaSjEsiVQYUOloUTjWjKNyQpcTrxZ-HM0MfHeRWW6TgzGj5GjFq7XjBLCMvRqgqrgYwzG8l1wvQhfHEH-YyLP33DIJxMz_OLAPMre6H_wn2vkG_ldcHw
CitedBy_id crossref_primary_10_3390_v10040193
crossref_primary_10_1371_journal_pntd_0007299
crossref_primary_10_3390_vaccines9090946
crossref_primary_10_1016_j_virol_2016_01_001
crossref_primary_10_1038_s44298_024_00031_7
crossref_primary_10_3390_v10090453
crossref_primary_10_3390_v10100541
crossref_primary_10_3390_v9110338
crossref_primary_10_1016_j_antiviral_2022_105511
crossref_primary_10_1007_s00705_022_05697_z
crossref_primary_10_3390_v14071501
crossref_primary_10_3389_fmicb_2019_01465
crossref_primary_10_4137_BCI_S30379
crossref_primary_10_3390_ijms20051101
crossref_primary_10_3390_v11010068
crossref_primary_10_1186_s13567_021_00966_2
crossref_primary_10_3390_membranes11050335
crossref_primary_10_1016_j_virusres_2020_198065
crossref_primary_10_1038_s41598_024_63407_y
crossref_primary_10_1016_j_phymed_2023_154976
crossref_primary_10_1016_j_virol_2020_09_001
crossref_primary_10_1128_JVI_00447_16
crossref_primary_10_3389_fnmol_2018_00116
crossref_primary_10_3390_v9110326
crossref_primary_10_1016_j_celrep_2019_08_005
crossref_primary_10_1099_jgv_0_001991
crossref_primary_10_1038_s41598_017_16475_2
crossref_primary_10_1074_mcp_R116_065649
crossref_primary_10_1128_JVI_01455_17
crossref_primary_10_1016_j_celrep_2017_03_071
crossref_primary_10_1038_srep44642
crossref_primary_10_1152_ajpcell_00028_2022
crossref_primary_10_1007_s00018_018_2968_8
crossref_primary_10_1016_j_vetmic_2021_109262
crossref_primary_10_1128_JVI_00618_20
crossref_primary_10_1016_j_virol_2016_11_002
crossref_primary_10_1038_s41541_018_0072_6
crossref_primary_10_1007_s00253_021_11364_1
crossref_primary_10_1016_j_tibs_2020_12_007
crossref_primary_10_1007_s00705_022_05632_2
crossref_primary_10_3390_vaccines12020215
crossref_primary_10_3390_v12101116
crossref_primary_10_1007_s12035_017_0635_y
crossref_primary_10_1016_j_antiviral_2020_104884
crossref_primary_10_1128_JVI_00573_21
crossref_primary_10_3390_v14081808
crossref_primary_10_1128_mra_00841_23
crossref_primary_10_3390_v10080422
crossref_primary_10_1128_JVI_00104_20
crossref_primary_10_1016_j_virusres_2016_11_029
crossref_primary_10_1080_09712119_2022_2026361
crossref_primary_10_1016_j_plipres_2016_09_005
crossref_primary_10_1016_j_antiviral_2019_04_003
crossref_primary_10_1186_s12985_023_02172_2
crossref_primary_10_1080_21645515_2020_1826798
crossref_primary_10_1111_1348_0421_12458
crossref_primary_10_1371_journal_pntd_0005019
crossref_primary_10_3390_v13081479
crossref_primary_10_1016_j_curtheres_2017_10_003
crossref_primary_10_1128_JVI_00694_16
crossref_primary_10_1099_jgv_0_001927
crossref_primary_10_1080_07391102_2020_1862707
crossref_primary_10_3390_v13112293
crossref_primary_10_3389_fmicb_2017_00110
crossref_primary_10_1016_j_isci_2019_02_012
crossref_primary_10_1099_jgv_0_001647
crossref_primary_10_1016_j_antiviral_2022_105423
crossref_primary_10_3390_vaccines8020170
crossref_primary_10_1038_s41598_021_02929_1
crossref_primary_10_1021_acs_chemrev_7b00719
Cites_doi 10.1126/science.1153264
10.1371/journal.pntd.0000311
10.1038/sj.embor.embor866
10.1128/JVI.77.7.4370-4382.2003
10.1099/vir.0.034793-0
10.1016/j.virol.2012.07.011
10.1111/j.1462-5822.2004.00480.x
10.1128/JVI.77.12.7143-7149.2003
10.1128/JVI.75.22.10787-10799.2001
10.1007/978-3-0346-0277-8_13
10.1093/nar/gkm1051
10.1007/s00705-009-0350-8
10.4149/av_2013_01_27
10.1016/j.virol.2009.01.038
10.1099/vir.0.044453-0
10.1002/jmv.20205
10.1128/JVI.72.7.5967-5977.1998
10.1074/jbc.M605429200
10.1099/vir.0.007872-0
10.1186/1743-422X-8-138
10.1128/JVI.76.11.5480-5491.2002
10.1126/science.1185181
10.1073/pnas.0832193100
10.1016/0042-6822(85)90129-1
10.1016/0042-6822(88)90161-4
10.1016/j.antiviral.2012.10.007
10.1099/vir.0.81252-0
10.1038/nsmb.2463
10.1128/JVI.01735-06
10.3390/ijerph10127144
10.1038/nrmicro1067
10.1016/j.jsb.2013.04.005
10.1007/s00705-013-1688-5
10.1128/JVI.79.18.11813-11823.2005
10.1016/j.vaccine.2014.03.091
10.1016/j.cell.2005.11.042
10.1371/journal.pone.0008325
10.1073/pnas.051631398
10.1128/JVI.00037-07
10.1038/nrmicro1928
10.1126/science.1153263
10.1099/vir.0.81320-0
10.1128/JVI.02120-06
10.1016/j.chom.2009.03.007
10.1016/j.virol.2007.05.007
10.1186/1423-0127-17-39
10.1128/JVI.01552-13
10.1099/vir.0.012120-0
10.1099/vir.0.064121-0
10.1371/journal.ppat.1000632
10.1128/JVI.00116-07
10.1016/j.virusres.2008.02.008
10.1016/j.jsb.2013.11.001
10.1016/j.virol.2011.02.022
10.1128/JVI.71.11.8475-8481.1997
10.1084/jem.20021840
10.4269/ajtmh.1980.29.948
10.1128/JVI.77.21.11357-11366.2003
10.1016/S0042-6822(03)00536-1
10.1016/j.vaccine.2010.07.055
10.1099/vir.0.80247-0
10.1128/JVI.74.1.24-32.2000
10.1371/journal.ppat.1000718
10.1016/j.tim.2011.02.002
10.1073/pnas.0305892101
10.1128/JVI.68.6.3794-3802.1994
10.1128/JVI.01025-09
10.1099/vir.0.036525-0
10.1006/viro.1996.0406
10.1128/JVI.00937-14
10.1182/blood-2012-05-430090
10.1038/nature07013
10.1016/j.micinf.2010.04.005
10.1007/BF01718326
10.1128/JVI.00789-08
10.1128/JVI.01900-09
10.1016/j.micinf.2010.10.014
10.1128/JVI.00696-10
10.1093/infdis/jir173
10.1038/nm1144
10.1007/s00705-004-0463-z
10.1099/vir.0.80283-0
10.1016/j.jsb.2006.09.002
10.1128/JVI.00940-14
10.1074/jbc.M114.610428
10.1128/JVI.67.3.1672-1675.1993
10.1073/pnas.90.13.6218
10.4269/ajtmh.2010.09-0262
10.1016/S0092-8674(02)00660-8
10.1371/journal.pntd.0000934
10.1016/j.vaccine.2013.08.027
10.1016/0042-6822(92)90745-B
10.1099/vir.0.18723-0
10.1016/j.str.2004.04.024
10.1089/vim.2004.17.461
10.1099/vir.0.81236-0
10.1637/9743-032811-Reg.1
10.1016/j.virol.2011.01.003
10.1016/0042-6822(87)90460-0
10.4269/ajtmh.2011.10-0439
10.1099/0022-1317-73-11-2999
10.1128/JVI.06072-11
10.1128/JVI.78.1.178-186.2004
10.1099/vir.0.015339-0
10.1128/JVI.76.7.3534-3543.2002
10.1016/j.bbrc.2005.01.121
10.1128/JVI.00118-14
10.1128/JVI.79.21.13262-13274.2005
10.1093/emboj/cdg270
10.1128/JVI.78.5.2367-2381.2004
10.1186/1471-2180-13-194
10.1042/BJ20112219
10.1016/j.cell.2010.07.038
10.1016/j.chom.2009.04.001
10.1128/JVI.01637-09
10.1128/JVI.69.9.5816-5820.1995
10.1016/j.str.2004.06.019
10.1006/viro.1997.8629
10.1016/S0042-6822(95)80018-2
10.1006/viro.1997.8608
10.1371/journal.ppat.1002655
10.1074/jbc.M111.226142
10.1128/JVI.01125-06
10.1016/j.virol.2010.11.006
10.1111/j.1462-5822.2011.01649.x
10.1128/JVI.77.1.443-451.2003
10.1128/JVI.79.6.3448-3458.2005
10.1111/j.1749-6632.2001.tb02719.x
10.1099/vir.0.055269-0
10.1128/JVI.79.13.8339-8347.2005
10.1016/j.antiviral.2011.10.017
10.1038/375291a0
10.1074/jbc.M112.384446
10.1006/viro.1993.1252
10.1099/vir.0.035964-0
10.1128/JVI.01180-08
10.1099/0022-1317-74-12-2653
10.1016/j.chom.2010.07.007
10.1099/vir.0.015255-0
10.1128/JVI.78.15.8078-8084.2004
10.1038/embor.2011.75
10.1007/BF01309477
10.1099/vir.0.2008/003731-0
10.1006/viro.1993.1006
10.1128/JVI.02653-08
10.1074/jbc.M504337200
10.1128/JVI.73.10.8083-8094.1999
10.1128/JVI.80.3.1290-1301.2006
10.1016/j.virol.2010.02.008
10.1128/JVI.72.3.2141-2149.1998
10.1006/viro.1997.8570
10.3201/eid1402.070457
10.1016/j.vaccine.2004.11.068
10.1371/journal.pone.0024365
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1099/vir.0.000097
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1465-2099
EndPage 1569
ExternalDocumentID 10_1099_vir_0_000097
25711963
Genre Journal Article
Review
GroupedDBID ---
-~X
.55
.GJ
186
18M
2WC
39C
3O-
4.4
53G
5GY
5RE
AAJMC
ABDNZ
ACBTR
ACGFO
ACPEE
ACYGS
ADBBV
ADCDP
ADCOW
AEILP
AENEX
AFFNX
AGCDD
AI.
AJKYU
ALMA_UNASSIGNED_HOLDINGS
BAWUL
C1A
CGR
CJ0
CS3
CUY
CVF
DIK
DU5
E3Z
EBS
ECM
EIF
EJD
F5P
FRP
GX1
H13
IH2
K-O
L7B
NPM
OHT
OK1
P2P
RGM
TR2
VH1
W8F
WH7
WHG
WOQ
X7M
Y6R
YKV
YSK
ZGI
~KM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c395t-22eb1652cf375412d8fd42e21fb4d4235f5bfd9966502b730c2e5be53d24b9d23
ISSN 0022-1317
IngestDate Fri Oct 25 22:42:02 EDT 2024
Thu Nov 21 22:03:54 EST 2024
Tue Oct 15 23:53:47 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue Pt 7
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c395t-22eb1652cf375412d8fd42e21fb4d4235f5bfd9966502b730c2e5be53d24b9d23
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink https://doi.org/10.1099/vir.0.000097
PMID 25711963
PQID 1708895339
PQPubID 23479
PageCount 19
ParticipantIDs proquest_miscellaneous_1708895339
crossref_primary_10_1099_vir_0_000097
pubmed_primary_25711963
PublicationCentury 2000
PublicationDate 2015-Jul
2015-07-01
20150701
PublicationDateYYYYMMDD 2015-07-01
PublicationDate_xml – month: 07
  year: 2015
  text: 2015-Jul
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Journal of general virology
PublicationTitleAlternate J Gen Virol
PublicationYear 2015
References r2
r3
r5
r8
r9
r90
r92
r100
r94
r93
r95
r10
r98
r97
r12
r11
r99
r14
r13
r16
r15
r18
r17
r19
Monath (r91) 1980; 29
Amberg (r6) 1999; 73
r21
r20
r23
r22
r25
r24
r27
r26
r29
r28
Roby (r117) 2012
r120
r121
r122
r30
Gubler (r37) 2012
r32
r116
r31
r34
r118
r33
r119
r36
r112
r35
r113
r38
r114
r115
r39
Amberg (r7) 1994; 68
r110
r111
r41
r40
r43
r105
r42
r106
r45
r107
r44
r108
r47
r101
r46
r102
r49
r103
r48
r109
r141
r142
r143
r144
r50
Lindenbach (r70) 2007
r52
r51
r140
r138
r53
r139
r56
r55
r58
r134
r135
Khromykh (r54) 1998; 72
r136
r59
Muller (r96) 2012
r137
King (r57) 2012
r132
r133
r61
r63
r62
r65
r127
r64
r128
Stadler (r130) 1997; 71
r67
r129
r66
r69
r123
r68
r124
r125
r126
Stocks (r131) 1998; 72
r72
r71
r160
r74
r73
r76
r75
r78
r77
Allison (r4) 1995; 69
r156
r79
r157
r158
r159
Konishi (r60) 1993; 67
r152
r153
r81
r154
r80
r155
r83
r82
r85
r150
r84
r151
r87
r149
r86
r89
r88
r145
r146
r147
r148
Olson (r104) 2012
r1
References_xml – ident: r150
  doi: 10.1126/science.1153264
– ident: r63
  doi: 10.1371/journal.pntd.0000311
– ident: r100
  doi: 10.1038/sj.embor.embor866
– ident: r76
  doi: 10.1128/JVI.77.7.4370-4382.2003
– start-page: 297
  volume-title: Molecular Virology and Control of Flaviviruses
  year: 2012
  ident: r104
  article-title: Flavivirus–vector interactions
  contributor:
    fullname: Olson
– ident: r113
  doi: 10.1099/vir.0.034793-0
– ident: r17
  doi: 10.1016/j.virol.2012.07.011
– ident: r61
  doi: 10.1111/j.1462-5822.2004.00480.x
– ident: r45
  doi: 10.1128/JVI.77.12.7143-7149.2003
– ident: r81
  doi: 10.1128/JVI.75.22.10787-10799.2001
– ident: r116
  doi: 10.1007/978-3-0346-0277-8_13
– ident: r44
  doi: 10.1093/nar/gkm1051
– ident: r74
  doi: 10.1007/s00705-009-0350-8
– ident: r152
  doi: 10.4149/av_2013_01_27
– ident: r94
  doi: 10.1016/j.virol.2009.01.038
– ident: r126
  doi: 10.1099/vir.0.044453-0
– ident: r127
  doi: 10.1002/jmv.20205
– volume: 72
  start-page: 5967
  year: 1998
  ident: r54
  article-title: Encapsidation of the flavivirus kunjin replicon RNA by using a complementation system providing Kunjin virus structural proteins in trans
  publication-title: J Virol
  doi: 10.1128/JVI.72.7.5967-5977.1998
  contributor:
    fullname: Khromykh
– ident: r26
  doi: 10.1074/jbc.M605429200
– ident: r132
  doi: 10.1099/vir.0.007872-0
– ident: r157
  doi: 10.1186/1743-422X-8-138
– ident: r75
  doi: 10.1128/JVI.76.11.5480-5491.2002
– ident: r28
  doi: 10.1126/science.1185181
– ident: r89
  doi: 10.1073/pnas.0832193100
– ident: r143
  doi: 10.1016/0042-6822(85)90129-1
– ident: r84
  doi: 10.1016/0042-6822(88)90161-4
– ident: r3
  doi: 10.1016/j.antiviral.2012.10.007
– ident: r88
  doi: 10.1099/vir.0.81252-0
– ident: r160
  doi: 10.1038/nsmb.2463
– volume-title: Virus Taxonomy: Classification and Nomenclature of Viruses: Ninth Report of the International Committee on Taxonomy of Viruses
  year: 2012
  ident: r57
  contributor:
    fullname: King
– ident: r49
  doi: 10.1128/JVI.01735-06
– ident: r50
  doi: 10.3390/ijerph10127144
– ident: r95
  doi: 10.1038/nrmicro1067
– ident: r159
  doi: 10.1016/j.jsb.2013.04.005
– ident: r2
  doi: 10.1007/s00705-013-1688-5
– ident: r31
  doi: 10.1128/JVI.79.18.11813-11823.2005
– ident: r105
  doi: 10.1016/j.vaccine.2014.03.091
– ident: r111
  doi: 10.1016/j.cell.2005.11.042
– ident: r139
  doi: 10.1371/journal.pone.0008325
– start-page: 1
  volume-title: Molecular Virology and Control of Flaviviruses
  year: 2012
  ident: r37
  article-title: Flaviviruses: past, present and future
  contributor:
    fullname: Gubler
– ident: r110
  doi: 10.1073/pnas.051631398
– ident: r155
  doi: 10.1128/JVI.00037-07
– ident: r98
  doi: 10.1038/nrmicro1928
– ident: r68
  doi: 10.1126/science.1153263
– ident: r67
  doi: 10.1099/vir.0.81320-0
– ident: r106
  doi: 10.1128/JVI.02120-06
– ident: r142
  doi: 10.1016/j.chom.2009.03.007
– ident: r15
  doi: 10.1016/j.virol.2007.05.007
– ident: r69
  doi: 10.1186/1423-0127-17-39
– ident: r118
  doi: 10.1128/JVI.01552-13
– ident: r39
  doi: 10.1099/vir.0.012120-0
– ident: r119
  doi: 10.1099/vir.0.064121-0
– ident: r122
  doi: 10.1371/journal.ppat.1000632
– ident: r92
  doi: 10.1128/JVI.00116-07
– ident: r86
  doi: 10.1016/j.virusres.2008.02.008
– ident: r109
  doi: 10.1016/j.jsb.2013.11.001
– ident: r129
  doi: 10.1016/j.virol.2011.02.022
– volume: 71
  start-page: 8475
  year: 1997
  ident: r130
  article-title: Proteolytic activation of tick-borne encephalitis virus by furin
  publication-title: J Virol
  doi: 10.1128/JVI.71.11.8475-8481.1997
  contributor:
    fullname: Stadler
– ident: r133
  doi: 10.1084/jem.20021840
– volume: 29
  start-page: 948
  year: 1980
  ident: r91
  article-title: Variation in virulence for mice and rhesus monkeys among St. Louis encephalitis virus strains of different origin
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.1980.29.948
  contributor:
    fullname: Monath
– ident: r5
  doi: 10.1128/JVI.77.21.11357-11366.2003
– ident: r18
  doi: 10.1016/S0042-6822(03)00536-1
– ident: r103
  doi: 10.1016/j.vaccine.2010.07.055
– ident: r128
  doi: 10.1099/vir.0.80247-0
– ident: r65
  doi: 10.1128/JVI.74.1.24-32.2000
– ident: r120
  doi: 10.1371/journal.ppat.1000718
– ident: r121
  doi: 10.1016/j.tim.2011.02.002
– ident: r80
  doi: 10.1073/pnas.0305892101
– volume: 68
  start-page: 3794
  year: 1994
  ident: r7
  article-title: NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies
  publication-title: J Virol
  doi: 10.1128/JVI.68.6.3794-3802.1994
  contributor:
    fullname: Amberg
– ident: r125
  doi: 10.1128/JVI.01025-09
– ident: r25
  doi: 10.1099/vir.0.036525-0
– ident: r99
  doi: 10.1006/viro.1996.0406
– ident: r107
  doi: 10.1128/JVI.00937-14
– ident: r146
  doi: 10.1182/blood-2012-05-430090
– ident: r19
  doi: 10.1038/nature07013
– ident: r12
  doi: 10.1016/j.micinf.2010.04.005
– ident: r53
  doi: 10.1007/BF01718326
– ident: r56
  doi: 10.1128/JVI.00789-08
– ident: r66
  doi: 10.1128/JVI.01900-09
– ident: r22
  doi: 10.1016/j.micinf.2010.10.014
– ident: r47
  doi: 10.1128/JVI.00696-10
– ident: r29
  doi: 10.1093/infdis/jir173
– ident: r82
  doi: 10.1038/nm1144
– ident: r136
  doi: 10.1007/s00705-004-0463-z
– ident: r114
  doi: 10.1099/vir.0.80283-0
– ident: r156
  doi: 10.1016/j.jsb.2006.09.002
– ident: r134
  doi: 10.1128/JVI.00940-14
– ident: r43
  doi: 10.1074/jbc.M114.610428
– volume: 67
  start-page: 1672
  year: 1993
  ident: r60
  article-title: Proper maturation of the Japanese encephalitis virus envelope glycoprotein requires cosynthesis with the premembrane protein
  publication-title: J Virol
  doi: 10.1128/JVI.67.3.1672-1675.1993
  contributor:
    fullname: Konishi
– ident: r71
  doi: 10.1073/pnas.90.13.6218
– ident: r97
  doi: 10.4269/ajtmh.2010.09-0262
– ident: r62
  doi: 10.1016/S0092-8674(02)00660-8
– start-page: 1101
  volume-title: Fields Virology
  year: 2007
  ident: r70
  article-title: Flaviviridae: the viruses and their replication
  contributor:
    fullname: Lindenbach
– ident: r140
  doi: 10.1371/journal.pntd.0000934
– ident: r52
  doi: 10.1016/j.vaccine.2013.08.027
– ident: r112
  doi: 10.1016/0042-6822(92)90745-B
– ident: r32
  doi: 10.1099/vir.0.18723-0
– ident: r30
  doi: 10.1016/j.str.2004.04.024
– ident: r83
  doi: 10.1089/vim.2004.17.461
– ident: r137
  doi: 10.1099/vir.0.81236-0
– ident: r135
  doi: 10.1637/9743-032811-Reg.1
– ident: r35
  doi: 10.1016/j.virol.2011.01.003
– ident: r145
  doi: 10.1016/0042-6822(87)90460-0
– ident: r14
  doi: 10.4269/ajtmh.2011.10-0439
– ident: r16
  doi: 10.1099/0022-1317-73-11-2999
– ident: r78
  doi: 10.1128/JVI.06072-11
– start-page: 51
  volume-title: Molecular Virology and Control of Flaviviruses
  year: 2012
  ident: r96
  article-title: ). The many faces of the flavivirus non-structural glycoprotein NS1
  contributor:
    fullname: Muller
– ident: r72
  doi: 10.1128/JVI.78.1.178-186.2004
– ident: r23
  doi: 10.1099/vir.0.015339-0
– ident: r58
  doi: 10.1128/JVI.76.7.3534-3543.2002
– ident: r11
  doi: 10.1016/j.bbrc.2005.01.121
– ident: r48
  doi: 10.1128/JVI.00118-14
– ident: r40
  doi: 10.1128/JVI.79.21.13262-13274.2005
– ident: r153
  doi: 10.1093/emboj/cdg270
– ident: r51
  doi: 10.1128/JVI.78.5.2367-2381.2004
– ident: r79
  doi: 10.1186/1471-2180-13-194
– ident: r87
  doi: 10.1042/BJ20112219
– ident: r21
  doi: 10.1016/j.cell.2010.07.038
– ident: r33
  doi: 10.1016/j.chom.2009.04.001
– ident: r151
  doi: 10.1128/JVI.01637-09
– volume: 69
  start-page: 5816
  year: 1995
  ident: r4
  article-title: Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form
  publication-title: J Virol
  doi: 10.1128/JVI.69.9.5816-5820.1995
  contributor:
    fullname: Allison
– ident: r154
  doi: 10.1016/j.str.2004.06.019
– ident: r144
  doi: 10.1006/viro.1997.8629
– ident: r1
  doi: 10.1016/S0042-6822(95)80018-2
– ident: r85
  doi: 10.1006/viro.1997.8608
– ident: r20
  doi: 10.1371/journal.ppat.1002655
– ident: r141
  doi: 10.1074/jbc.M111.226142
– ident: r102
  doi: 10.1128/JVI.01125-06
– ident: r42
  doi: 10.1016/j.virol.2010.11.006
– ident: r8
  doi: 10.1111/j.1462-5822.2011.01649.x
– ident: r59
  doi: 10.1128/JVI.77.1.443-451.2003
– ident: r93
  doi: 10.1128/JVI.79.6.3448-3458.2005
– ident: r123
  doi: 10.1111/j.1749-6632.2001.tb02719.x
– ident: r149
  doi: 10.1099/vir.0.055269-0
– ident: r10
  doi: 10.1128/JVI.79.13.8339-8347.2005
– ident: r9
  doi: 10.1016/j.antiviral.2011.10.017
– ident: r115
  doi: 10.1038/375291a0
– ident: r158
  doi: 10.1074/jbc.M112.384446
– ident: r38
  doi: 10.1006/viro.1993.1252
– ident: r148
  doi: 10.1099/vir.0.035964-0
– ident: r46
  doi: 10.1128/JVI.01180-08
– ident: r138
  doi: 10.1099/0022-1317-74-12-2653
– ident: r34
  doi: 10.1016/j.chom.2010.07.007
– ident: r90
  doi: 10.1099/vir.0.015255-0
– ident: r55
  doi: 10.1128/JVI.78.15.8078-8084.2004
– ident: r108
  doi: 10.1038/embor.2011.75
– ident: r101
  doi: 10.1007/BF01309477
– ident: r41
  doi: 10.1099/vir.0.2008/003731-0
– ident: r147
  doi: 10.1006/viro.1993.1006
– ident: r124
  doi: 10.1128/JVI.02653-08
– ident: r77
  doi: 10.1074/jbc.M504337200
– volume: 73
  start-page: 8083
  year: 1999
  ident: r6
  article-title: Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing
  publication-title: J Virol
  doi: 10.1128/JVI.73.10.8083-8094.1999
  contributor:
    fullname: Amberg
– ident: r27
  doi: 10.1128/JVI.80.3.1290-1301.2006
– start-page: 21
  volume-title: Molecular Virology and Control of Flaviviruses
  year: 2012
  ident: r117
  article-title: Flavivirus replication and assembly
  contributor:
    fullname: Roby
– ident: r73
  doi: 10.1016/j.virol.2010.02.008
– volume: 72
  start-page: 2141
  year: 1998
  ident: r131
  article-title: Signal peptidase cleavage at the flavivirus C–prM junction: dependence on the viral NS2B-3 protease for efficient processing requires determinants in C, the signal peptide, and prM
  publication-title: J Virol
  doi: 10.1128/JVI.72.3.2141-2149.1998
  contributor:
    fullname: Stocks
– ident: r64
  doi: 10.1006/viro.1997.8570
– ident: r13
  doi: 10.3201/eid1402.070457
– ident: r36
  doi: 10.1016/j.vaccine.2004.11.068
– ident: r24
  doi: 10.1371/journal.pone.0024365
SSID ssj0014457
Score 2.4968219
SecondaryResourceType review_article
Snippet Flaviviruses are a group of single-stranded, positive-sense RNA viruses that generally circulate between arthropod vectors and susceptible vertebrate hosts,...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
StartPage 1551
SubjectTerms Capsid Proteins - metabolism
Flavivirus - physiology
Gene Expression Regulation, Viral
Glycosylation
Host-Pathogen Interactions
Humans
Protein Multimerization
Protein Processing, Post-Translational
Proteolysis
Viral Envelope Proteins - metabolism
Virus Assembly
Virus Release
Title Post-translational regulation and modifications of flavivirus structural proteins
URI https://www.ncbi.nlm.nih.gov/pubmed/25711963
https://search.proquest.com/docview/1708895339
Volume 96
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fT9swELaAaRIvCAaMwpg8CZ6qQO3ESfM4TQM0tGn8krqnKE5sqKAJKgGp_PXc2UncCpAGL1Fkt07r73S-u3x3R8hOrPpcRSL3wDiOwEHxc6_fl6HHopT7fsolizA5-fef8Ogi-DUQA0e3NdklldzLHl_MK3kPqjAGuGKW7BuQbReFAbgHfOEKCMP1vzDGTrtehafNTRPTG9ve8g3JeFTmyAVyfDd9kz4MH4bj-7uuLR1rym6Yag3DOnD33FS9tLWpu5gTNx2FPy1tXU7TEqxwYdEzVZUmXPMPRgcggJdO0dnXHKflxH38-GpcjibXVzMJN_V0HZBgoiWvwnlilWiAzLmebXzUaFnbt7aWpr9VN5rSmmi2vajOYQ3AAP7cXs8UmrRU3ilkb0cGWtA7DFWJO9RaqmEzNU8-YK1EbK9wOGhZQOBOiqjOh4CH7U8_CutE11-eNVpe8USMRXK-TJZqfOh3KxcrZE4Vn8hH21x0skpOnksHddJBYZPpjHTQUlMnHdRJB22kY41cHPw8_3Hk1Q00vMyPReVxDidxKHimsdEx43lf5wFXnGkZwI0vtJA6R49X9LgEXZ9xJaQSfs4DGefcXycLRVmoDUJZJpXMwOBTLA40-NBpGqaK6Zhr4fM07JDdZoeSW1snJbH8hjiBn51gEVrc1A751mxfAooM306lhSrv7xIWIeMOvI-4Qz7bfW1XanDYfHVmiyw6WfxCFmCP1DaYi5X8agB_Amyrbj4
link.rule.ids 314,780,784,27924,27925
linkProvider Geneva Foundation for Medical Education and Research
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Post-translational+regulation+and+modifications+of+flavivirus+structural+proteins&rft.jtitle=Journal+of+general+virology&rft.au=Roby%2C+Justin+A&rft.au=Setoh%2C+Yin+Xiang&rft.au=Hall%2C+Roy+A&rft.au=Khromykh%2C+Alexander+A&rft.date=2015-07-01&rft.eissn=1465-2099&rft.volume=96&rft.issue=Pt+7&rft.spage=1551&rft_id=info:doi/10.1099%2Fvir.0.000097&rft_id=info%3Apmid%2F25711963&rft.externalDocID=25711963
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-1317&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-1317&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-1317&client=summon