Prooxidant capacity of phenolic acids defines antioxidant potential

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 7; p. 130371
• Main Authors: Mu, Kaiwen, Yao, Yufeng, Wang, Danni, Kitts, David D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2023
• Subjects: antioxidant activity; Antioxidants - metabolism; Antioxidants - pharmacology; Aquaporin; aquaporins; autoxidation; Caco-2 Cells; catalase; epithelium; H2O2; human nutrition; Humans; Hydrogen Peroxide - metabolism; HyPer-3; intestines; Kelch-Like ECH-Associated Protein 1 - metabolism; NF-E2-Related Factor 2 - metabolism; Nrf2 cell signaling; oxidative stress; Phenolic acids; Reactive Oxygen Species - metabolism; HyPer-3; Keap 1; Caco-2 cells; AAPH; H2O2; MTT; AQP3; Phenolic acids; DMEM; ANOVA; Nrf2; FBS; GA; CGA; LSD's; CA; AQP; PBS; SDS; Nrf2 cell signaling; DCFH-DA; ARE; ROS; FA; HBSS; Aquaporin; ELISA; HO

Phenolic acids derived from vegetables, fruits and beverages are considered abundant sources of natural antioxidants consumed in the human diet. In addition to having well-known antioxidant activity, phenolic acids also exhibit pro-oxidant activity under selected conditions. We hypothesized that the...