Calcium signaling mechanisms disrupt the cytoskeleton of primary astrocytes and neurons exposed to diphenylditelluride

• Published in: Biochimica et biophysica acta Vol. 1860; no. 11; pp. 2510 - 2520
• Main Authors: Heimfarth, Luana, da Silva Ferreira, Fernanda, Pierozan, Paula, Loureiro, Samanta Oliveira, Mingori, Moara Rodrigues, Moreira, José Cláudio Fonseca, da Rocha, João Batista Teixeira, Pessoa-Pureur, Regina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2016
• Subjects: Actin Cytoskeleton - metabolism; Animals; antagonists; Astrocyte; astrocytes; Astrocytes - drug effects; Astrocytes - metabolism; Benzene Derivatives - pharmacology; Benzene Derivatives - toxicity; brain; Calcium; calcium channels; Calcium Signaling; cAMP-dependent protein kinase; Cell signaling; Cells, Cultured; Cytoskeleton; Diphenylditelluride; enzyme inhibitors; glutamate receptors; homeostasis; intermediate filaments; mitogen-activated protein kinase; neurodegenerative diseases; Neuron; neurons; Neurons - drug effects; Neurons - metabolism; neurotoxins; Organometallic Compounds - pharmacology; Organometallic Compounds - toxicity; orthophosphates; phospholipase C; phosphorus; protein kinase C; radionuclides; Rats; Rats, Wistar; vimentin; Cytoskeleton; Neuron; Astrocyte; Calcium; Cell signaling; Diphenylditelluride

Diphenylditelluride (PhTe)2 is a potent neurotoxin disrupting the homeostasis of the cytoskeleton. Cultured astrocytes and neurons were incubated with (PhTe)2, receptor antagonists and enzyme inhibitors followed by measurement of the incorporation of [32P]orthophosphate into intermediate filaments (...