Multifaceted functions of the forkhead box transcription factors FoxO1 and FoxO3 in skin

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1057 - 1064
• Main Authors: Tsitsipatis, Dimitrios, Klotz, Lars-Oliver, Steinbrenner, Holger
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: acne; Animals; antioxidant activity; apoptosis; biosynthesis; cell cycle; Epidermis; fibroblasts; Fibroblasts - metabolism; Forkhead Box Protein O1 - metabolism; Forkhead Box Protein O3 - metabolism; gene regulatory networks; genes; homeostasis; Humans; IGF-1; keratinocytes; Keratinocytes - metabolism; maintenance and repair; mammals; melanin; melanocytes; Melanocytes - metabolism; Melanogenesis; melanoma; metastasis; morphogenesis; oxidative stress; p63; Skin - metabolism; skin neoplasms; transcription factors; Transcription Factors - metabolism; Wound healing; UV; Epidermis; IGF-1; Wound healing; Melanogenesis; p63

The ubiquitously expressed forkhead box, class O (FoxO) transcription factors act as signaling integrators in extensive transcriptional networks, ensuring maintenance of cell and tissue homeostasis over time and in response to environmental challenges. Proteins whose biosynthesis is controlled throu...