The action of Echis carinatus and Naja naja venoms on human neutrophils; an emphasis on NETosis

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 6; p. 129561
• Main Authors: Swethakumar, Basavarajaiah, NaveenKumar, Somanathapura K., Girish, Kesturu S., Kemparaju, Kempaiah
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2020
• Subjects: calcium; Calcium ions; cell communication; cell viability; chromatin; cobra venoms; deoxyribonucleases; Echis carinatus; humans; innate immunity; mitochondrial DNA; mitogen-activated protein kinase; Naja naja; neutrophils; nuclear genome; pathophysiology; pharmacodynamics; protein kinase C; Reactive oxygen species; snake bites; snakes; Suicidal NETosis; toxicity; Vital NETosis; Reactive oxygen species; Suicidal NETosis; Echis carinatus; Naja naja; Vital NETosis; Calcium ions

Neutrophils are the first line defense cells of the innate immunity. As a final defense, they discharge their de-condensed chromatin/DNA fibers, the NETs (Neutrophil Extracellular Traps), by a process called NETosis. Two types of NETosis have been currently described: the suicidal/delayed/classical-...