The posttranslational modifications of Hippo-YAP pathway in cancer

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 1; p. 129397
• Main Authors: Yan, Fangjie, Qian, Meijia, He, Qiaojun, Zhu, Hong, Yang, Bo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2020
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Cancer; cancer therapy; carcinogenesis; Carcinogenesis - genetics; Drug Resistance, Neoplasm - genetics; Hippo pathway; Humans; metastasis; Neoplasm Metastasis; neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; phosphotransferases (kinases); post-translational modification; Posttranslational modifications; Protein Processing, Post-Translational - genetics; Protein-Serine-Threonine Kinases - genetics; Signal Transduction - genetics; transcription (genetics); Transcription Factors - genetics; Yes-associated protein; Yes-associated protein; Hippo pathway; Posttranslational modifications; Cancer

Yes-associated protein (YAP) is a key effector of the Hippo pathway and is frequently dysregulated in aggressive human cancers. Aberrant YAP activation has emerged as an important driver of tumorigenesis, chemoresistance and metastasis. Since posttranslational modifications (PTMs) are pivotal modifi...